[HTML][HTML] The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to …
…, KV Shah, KJ Hewitt, DT Rosenthal, FE Indig… - Journal of Biological …, 2007 - ASBMB
We have shown that Wnt5A increases the motility of melanoma cells. To explore cellular
pathways involving Wnt5A, we compared gain-of-function (WNT5A stable transfectants) versus …
pathways involving Wnt5A, we compared gain-of-function (WNT5A stable transfectants) versus …
Zscan4 regulates telomere elongation and genomic stability in ES cells
Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells.
However, the genes contributing to this stability remain obscure. We previously identified …
However, the genes contributing to this stability remain obscure. We previously identified …
Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2
…, S Widura, J Nelson, N Ruiz, TC Camilli, FE Indig… - Cancer discovery, 2013 - AACR
An emerging concept in melanoma biology is that of dynamic, adaptive phenotype switching,
where cells switch from a highly proliferative, poorly invasive phenotype to a highly invasive…
where cells switch from a highly proliferative, poorly invasive phenotype to a highly invasive…
Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1
…, X Yang, K Mazan-Mamczarz, FE Indig… - … and cellular biology, 2005 - Taylor & Francis
The RNA-binding protein TIA-1 (T-cell intracellular antigen 1) functions as a posttranscriptional
regulator of gene expression and aggregates to form stress granules following cellular …
regulator of gene expression and aggregates to form stress granules following cellular …
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma
…, TC Camilli, AD French, SK Dissanayake, FE Indig… - Oncogene, 2010 - nature.com
Tyrosine kinase receptors represent targets of great interest for cancer therapy. Here we
show, for the first time, the importance of the orphan tyrosine kinase receptor, ROR2, in …
show, for the first time, the importance of the orphan tyrosine kinase receptor, ROR2, in …
HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP
…, J Curtis, CA Moad, CM Wohler, FE Indig… - Genes & …, 2016 - genesdev.cshlp.org
Some mitochondrial long noncoding RNAs (lncRNAs) are encoded by nuclear DNA, but the
mechanisms that mediate their transport to mitochondria are poorly characterized. Using …
mechanisms that mediate their transport to mitochondria are poorly characterized. Using …
Identification of senescent cell surface targetable protein DPP4
…, JL Martindale, X Yang, FE Indig… - Genes & …, 2017 - genesdev.cshlp.org
Senescent cell accumulation in aging tissues is linked to age-associated diseases and
declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that …
declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that …
Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility
…, DT Rosenthal, SK Dissanayake, R Earley, FE Indig… - Oncogene, 2007 - nature.com
Serial analysis of gene expression followed by pathway analysis implicated the tight junction
protein claudin-1 (CLDN1) in melanoma progression. Tight junction proteins regulate the …
protein claudin-1 (CLDN1) in melanoma progression. Tight junction proteins regulate the …
[HTML][HTML] Role of mitofusin 2 (Mfn2) in controlling cellular proliferation
KH Chen, A Dasgupta, J Ding, FE Indig… - The FASEB …, 2014 - ncbi.nlm.nih.gov
It has been reported that Mitofusin2 (Mfn2) inhibits cell proliferation when overexpressed. We
wanted to study the role of endogenous Mfn2 in cell proliferation, along with the structural …
wanted to study the role of endogenous Mfn2 in cell proliferation, along with the structural …
[HTML][HTML] PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells
…, BP Frank, S Subaran, FE Indig… - … journal of medical …, 2009 - ncbi.nlm.nih.gov
Cytoplasmic expression of claudin-1 in metastatic melanoma cells correlates to increased
migration, and increased secretion of MMP-2 in a PKC dependent manner, whereas claudin-1 …
migration, and increased secretion of MMP-2 in a PKC dependent manner, whereas claudin-1 …