We have shown that Wnt5A increases the motility of melanoma cells. To explore cellular
pathways involving Wnt5A, we compared gain-of-function (WNT5A stable transfectants) versus …

Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells.
However, the genes contributing to this stability remain obscure. We previously identified …

An emerging concept in melanoma biology is that of dynamic, adaptive phenotype switching,
where cells switch from a highly proliferative, poorly invasive phenotype to a highly invasive…

The RNA-binding protein TIA-1 (T-cell intracellular antigen 1) functions as a posttranscriptional
regulator of gene expression and aggregates to form stress granules following cellular …

Tyrosine kinase receptors represent targets of great interest for cancer therapy. Here we
show, for the first time, the importance of the orphan tyrosine kinase receptor, ROR2, in …

Some mitochondrial long noncoding RNAs (lncRNAs) are encoded by nuclear DNA, but the
mechanisms that mediate their transport to mitochondria are poorly characterized. Using …

Senescent cell accumulation in aging tissues is linked to age-associated diseases and
declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that …

Serial analysis of gene expression followed by pathway analysis implicated the tight junction
protein claudin-1 (CLDN1) in melanoma progression. Tight junction proteins regulate the …

It has been reported that Mitofusin2 (Mfn2) inhibits cell proliferation when overexpressed. We
wanted to study the role of endogenous Mfn2 in cell proliferation, along with the structural …

Cytoplasmic expression of claudin-1 in metastatic melanoma cells correlates to increased
migration, and increased secretion of MMP-2 in a PKC dependent manner, whereas claudin-1 …