In recent years, heparanase has attracted considerable attention as a promising target for
innovative pharmacological applications. Heparanase is a multifaceted protein endowed with …

Heparanase is a β-d-glucuronidase which cleaves heparan sulfate chains in the extracellular
matrix and on cellular membranes. A dysregulated heparanase activity is intimately …

Ruthenium catalyzed 1,3-cycloaddition (click chemistry) of an azido moiety installed on
dihydroxycumene scaffold with differently substituted aryl propiolates gave a new family of 1,4,5-…

As of December 2021, coronavirus disease 2019 (COVID-19), caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global emergency, and novel …

7-Azaindole-1-carboxamides were designed as a new class of PARP-1 inhibitors. The
compounds displayed a variable pattern of target inhibition profile that, in part, paralleled the …

A systematic study of medicinal chemistry aimed at identifying a new generation of HDAC
inhibitors, through the introduction of a thiol zinc-binding group (ZBG) and of an amide-lactam …

Heparanase is the sole mammalian enzyme capable of cleaving glycosaminoglycan
heparan sulfate side chains of heparan sulfate proteoglycans. Its altered activity is intimately …

Heparanase is the only mammalian endo-β-d-glucuronidase involved in a variety of major
diseases. The up-regulation of heparanase expression increases tumor size, angiogenesis, …

A structural investigation on the isoxazole scaffold led to the discovery of 3,4-isoxazolediamide
compounds endowed with potent Hsp90 inhibitory properties. We have found that …

A series of 3-aryl-naphtho[2,3–d]isoxazole-4,9-diones and some of their 6-aza analogues
were synthesized and found to inhibit the heat shock protein 90 (Hsp90). The compounds …