… HOFFMAN EC, REYES H, CHU FF, SANDER F, CONLEY LH, BROOKS BA, HANKINSON
0: Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252:954, 1991 18…

Hypoxia plays a fundamental role in the pathophysiology of common causes of mortality,
including ischemic heart disease, stroke, cancer, chronic lung disease, and congestive heart …

Studies on erythropoietin regulation led to discovery of hypoxia-inducible factor 1 (HIF-1), a
transcription factor which is central component of oxygen sensing mechanism in mammalian …

… Plasmid DNA was prepared by using commercial kits (Qiagen) and transfected into cells by
electroporation with a Gene Pulser (BioRad) at 260 V and 960 F. Duplicate electroporations …

… chimeric (F 0 ) males were mated to C57BL/6 females.Hif1a +/− F 1 mice were identified by
DNA blot hybridization analysis, and heterozygous littermates were mated. Among the 113 …

Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding glucose transporters,
glycolytic enzymes, vascular endothelial growth factor, and other proteins involved in …

Hypoxia-inducible factor 1 (HIF-1) transactivates genes the products of which mediate tumor
angiogenesis and glycolytic metabolism. Overexpression of the HIF-1α subunit, resulting …

Adaptation to hypoxia represents an important aspect of tumor progression. Hypoxia-inducible
factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to …

… All P values were derived from adjusted Wald F tests based on these regression models,
and P<.05 was considered statistically significant. All analyses were adjusted for stratification …

… Also shown are positive staining of pial (E) and positive HIF-1α immunostaining of the
epithelial (F) cells of the choroid plexus and the ependymal cells lining the lateral ventricles of …