User profiles for F. Manetti

Fabrizio Manetti

Professor, University of Siena (Italy)
Verified email at unisi.it
Cited by 8339

[HTML][HTML] Mental health consequences of COVID-19 pandemic period in the European population: an institutional challenge

…, D Morena, G Delogu, G Volonnino, F Manetti… - International journal of …, 2022 - mdpi.com
The worldwide spread of SARS-CoV-2 has been responsible for an infectious pandemic,
with repercussions on socio-economic aspects and on the physical and mental health of the …

LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators

F Manetti - Medicinal research reviews, 2012 - Wiley Online Library
… Dephosphorylated SSH-1L is much more active as cofilin phosphatase with respect to the
corresponding phosphorylated form and its activity strongly depends on the presence of F-…

4-Hydroxyphenylpyruvate dioxygenase and its inhibition in plants and animals: small molecules as herbicides and agents for the treatment of human inherited …

…, D Braconi, E Petricci, F Manetti - Journal of Medicinal …, 2017 - ACS Publications
This review mainly focuses on the physiological function of 4-hydroxyphenylpyruvate dioxygenase
(HPPD), as well as on the development and application of HPPD inhibitors of several …

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

…, TR Ioerger, JC Sacchettini, F Manetti… - Antimicrobial agents …, 2012 - Am Soc Microbiol
The 1,5-diarylpyrrole derivative BM212 was previously shown to be active against multidrug-resistant
clinical isolates and Mycobacterium tuberculosis residing within macrophages as …

Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones

D Castagnolo, F Manetti, M Radi, B Bechi… - Bioorganic & medicinal …, 2009 - Elsevier
Two series of novel rigid pyrazolone derivatives were synthesized and evaluated as inhibitors
of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. Two of these …

Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis

…, A De Logu, M Radi, B Bechi, F Manetti… - Bioorganic & medicinal …, 2008 - Elsevier
… Pyrazoles 1 and 2 were placed in six different reaction vessels and reacted in parallel with
different benzyl halides using a Büchi Syncore synthesizer affording pyrazolones 9a–f.8, 9 …

[HTML][HTML] Management of the corpse with suspect, probable or confirmed COVID-19 respiratory infection–Italian interim recommendations for personnel potentially …

…, M Gabbrielli, R La Russa, A Maiese, F Manetti… - Pathologica, 2020 - ncbi.nlm.nih.gov
Guidelines Management of the corpse with suspect, probable or confirmed COVID-19 respiratory
infection–Italian interim recommendations for personnel potentially exposed to material …

Antimycobacterial agents. Novel diarylpyrrole derivatives of BM212 endowed with high activity toward Mycobacterium tuberculosis and low cytotoxicity

…, R Pompei, P Molicotti, F Manetti… - Journal of medicinal …, 2006 - ACS Publications
f Compound submitted to an international patent application (see ref 37). … Merck TLC
plates, silica gel 60 F 254 were used for TLC. Fluka aluminum oxide (activity II−III, according to …

[HTML][HTML] Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

…, E De Rossi, B Wae, SG Franzblau, F Manetti… - PloS one, 2013 - journals.plos.org
1,5-Diphenyl pyrroles were previously identified as a class of compounds endowed with high
in vitro efficacy against M. tuberculosis. To improve the physical chemical properties and …

Synthesis, Biological Evaluation, and Pharmacophore Generation of New Pyridazinone Derivatives with Affinity toward α1- and α2-Adrenoceptors

…, G Giannaccini, L Maccari, F Manetti… - Journal of Medicinal …, 2001 - ACS Publications
… of a methoxy group (2a−f vs 2h−m, 1e,f vs 1k,l, and 3g,i,k vs 3h,j,l), in the others the general
trend goes in the opposite sense (1a−d vs 1g−j, 3a,c,e vs 3b,d,f, and 4a,c,e,g,i,k vs 4b,d,f,h,j,l)…