Signaling pathways for muscarinic acetylcholine receptors (mAChRs) include several enzymes
and ion channels. Recent studies have revealed the importance of various isoforms of …

The availability of radiolabelled ligands selective for various putative neurotransmitter
receptor sites and the development of quantitative autoradiography has led to a greater …

1 We review literature demonstrating (a) the presence and (b) the actions of substances that
mediate or modify neuroeffector transmission to the smooth muscle of the prostrate stroma …

The inhibitory effect of gallamine (1.1 muM-1.1 mM) on negative inotropic responses to
acetylcholine (ACh) or carbachol (CCh) was investigated in isolated electrically stimulated atria …

We investigated muscarinic receptors in the detrusor and mucosa of the human bladder body.
Radioligand-binding studies with [3 H] QNB were conducted using specimens collected …

The mammalian prostate is densely innervated by hypogastric and pelvic nerves that play
an important role in regulating the growth and function of the gland. While there has been …

The ability of the alkaloid, ebeinone, isolated from Fritillaria imperialis, to act at muscarinic
M 2 and M 3 acetylcholine receptors was investigated. In functional studies with guinea-pig …

1. An allosteric interaction occurs when the binding of a ligand to its site on a receptor is
able to modify the binding of another ligand to a topographically distinct site on the same …

Muscarinic agonists act mainly via muscarinic M 3 cholinoceptors to cause contraction of the
iris sphincter, ciliary muscle and trabecular meshwork as well as increase outflow facility of …

Recent studies have described muscarinic receptors on the mucosa and the detrusor of the
human urinary bladder. Muscarinic receptor antagonists are effective in the treatment of …