Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
F Okajima - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2002 - Elsevier
Sphingosine 1-phosphate (S1P) concentration in plasma and serum has been estimated to
be within 200–900 nM. Among plasma and serum components, S1P is concentrated in …
be within 200–900 nM. Among plasma and serum components, S1P is concentrated in …
Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors
H Tomura, C Mogi, K Sato, F Okajima - Cellular signalling, 2005 - Elsevier
OGR1, GPR4, G2A, and TDAG8 share 40% to 50% homology with each other and seem to
form a family of GPCRs. They have been described as receptors for lipid molecules such as …
form a family of GPCRs. They have been described as receptors for lipid molecules such as …
Regulation of inflammation by extracellular acidification and proton-sensing GPCRs
F Okajima - Cellular signalling, 2013 - Elsevier
Under ischemic and inflammatory circumstances, such as allergic airway asthma,
rheumatoid arthritis, atherosclerosis, and tumors, extracellular acidification occurs due to the …
rheumatoid arthritis, atherosclerosis, and tumors, extracellular acidification occurs due to the …
Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions
…, A KUWABARA, M UI, F OKAJIMA - Biochemical …, 2000 - portlandpress.com
… and Okajima, F. (1999) Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced
activation of extracellular signal-regulated kinase in C6 glioma cells. Mol. …
activation of extracellular signal-regulated kinase in C6 glioma cells. Mol. …
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors
…, DS Im, H Nochi, K Tamoto, H Tomura, F Okajima - Molecular …, 2003 - ASPET
Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors:
three subtypes of the EDG-family receptors, LPA 1 , LPA 2 , and LPA 3 (formerly known …
three subtypes of the EDG-family receptors, LPA 1 , LPA 2 , and LPA 3 (formerly known …
[HTML][HTML] Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
…, Y Sui, J Nabekura, K Sato, F Okajima… - Nature …, 2017 - nature.com
… d–f Three-dimensional reconstruction shows several pieces of debris (e, f, pink) are scattered
within single processes (e, f, white). g, h Astrocyte processes surround blood vessels (g, BV…
within single processes (e, f, white). g, h Astrocyte processes surround blood vessels (g, BV…
[HTML][HTML] Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial …
…, M Ishiwara, I Kobayashi, M Ui, F Okajima - Journal of Biological …, 2001 - ASBMB
Sphingosine 1-phosphate (S1P), a novel lipid mediator, is concentrated in the fraction of
lipoproteins that include high density lipoprotein (HDL) and low density lipoprotein (LDL) in …
lipoproteins that include high density lipoprotein (HDL) and low density lipoprotein (LDL) in …
High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors
…, A Kuwabara, M Murakami, F Okajima - … , and vascular biology, 2003 - Am Heart Assoc
Objective— Plasma high-density lipoprotein (HDL) level is inversely correlated with the risk
of atherosclerosis. However, the cellular mechanism by which HDL exerts antiatherogenic …
of atherosclerosis. However, the cellular mechanism by which HDL exerts antiatherogenic …
[HTML][HTML] TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor
…, A Harada, N Misawa, H Tomura, F Okajima - Journal of Biological …, 2004 - ASBMB
T cell death-associated gene 8 (TDAG8) has been reported to be a receptor for psychosine.
Ovarian cancer G-protein-coupled receptor 1 (OGR1) and GPR4, G-protein-coupled …
Ovarian cancer G-protein-coupled receptor 1 (OGR1) and GPR4, G-protein-coupled …
Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3
…, I Kobayashi, H Ohta, M Ui, F Okajima - Biochemical …, 2000 - portlandpress.com
Sphingosine 1-phosphate (S1P) stimulates thymidine incorporation (DNA synthesis), cell
growth and cell migration in human aortic endothelial cells (HAECs). The extent of the S1P-…
growth and cell migration in human aortic endothelial cells (HAECs). The extent of the S1P-…