… Supported by NIH grant GM 54887 to RHS We are deeply saddened by the loss of our
colleague and close friend Fredric S. Fay during the preparation of this manuscript. …

Calcium is believed to control a variety of cellular processes, often with a high degree of
spatial and temporal precision. For a cell to use Ca 2+ in this manner, mechanisms must exist …

… We dedicate this manuscript to the memory of Fredric S. Fay who served as an inspiration
for this work and a spirited friend. … We dedicate this manuscript to the memory of Fredric S. …

The concentration of intracellular free calcium ([Ca 2+ ] i ) in polarized eosinophils was imaged
during chemotaxis by monitoring fluorescence of the calcium-sensitive dye Fura-2 with a …

Fluorescent probes offer insight into the highly localized and rapid molecular events that
underlie cell function. However, methods are required that can efficiently transform the limited …

The mitogen-activated protein (MAP) kinase signal transduction pathway represents an
important mechanism by which growth factors regulate cell function. Targets of the MAP kinase …

Because of its importance in the chemiosmotic theory, mitochondrial membrane potential
has been the object of many investigations. Significantly, however, quantitative data on how …

A quantitative three-dimensional analysis of nuclear components involved in precursor
messenger RNA metabolism was performed with a combination of fluorescence hybridization, …

THE Na + /Ca 2 + exchanger, driven by a transmembrane Na + gradient, plays a key role in
regulating Ca 2+ concentration in many cells1'2. Although the exchanger influences Ca 2+ …

Human platelet-derived growth factor receptors (PDGFRs) expressed in human Hep G2
cells internalized and concentrated in a juxtanuclear region near the Golgi network within 10 …