Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of pentameric
ligand-gated cation channels that are expressed throughout the brain and involved in a …

Cigarette smoking is currently the leading cause of preventable deaths and disability throughout
the world, being responsible for about five million premature deaths/year. Unfortunately, …

Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Brain
inflammation is increasingly recognized as a critical factor for seizure precipitation, but the …

We examined α 7 β 2 -nicotinic acetylcholine receptor (α 7 β 2 -nAChR) expression in mammalian
brain and compared pharmacological profiles of homomeric α 7 -nAChRs and α 7 β 2 -…

Heteromeric nAChRs are pentameric cation channels, composed of combinations of two or
three α and three or two β subunits, which play key physiological roles in the central and …

Long-term nicotine exposure changes neuronal acetylcholine nicotinic receptor (nAChR)
subtype expression in the brains of smokers and experimental animals. The aim of this study …

Tobacco addiction is a complex form of dependence process that leads high relapse rates
in people seeking to stop smoking. Nicotine elicits its primary effects on neuronal nicotinic …

Neuropathic pain is a severe diabetes complication and its treatment is not satisfactory. It is
associated with neuroinflammation-related events that participate in pain generation and …

A series of unichiral 7-substituted 2-(1′-methyl-2′-pyrrolidinyl)-1,4-benzodioxanes were
synthesized and tested for the affinity for the α4β2 and α7 central nicotinic receptors; the 2R,2…

Myosin IXa (Myo9a) is a motor protein that is highly expressed in the brain. However, the
role of Myo9a in neurons remains unknown. Here, we investigated Myo9a function in …