Background Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs
of the yeast Sir2 gene. SIRT3 is the only sirtuin with a reported association with the human …

Micro-RNAs (miRNAs) have been suggested to play pivotal roles in multifarious diseases
associated with the posttranscriptional regulation of protein-coding genes. In this study, we …

The peroxisome proliferator-activated receptor-gamma (PPAR-γ) coactivator-1β (PGC-1β) is
a well-established regulator of the β-oxidation of fatty acids and the oxidative …

Promoting development and function of brown and beige fat may reduce obesity. Here, we
show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic …

The mechanisms underlying the muscle wasting that accompanies CKD are not well
understood. Animal models suggest that impaired differentiation of muscle progenitor cells may …

Chronic glucocorticoid therapy has serious side effects, including diabetes and fatty liver.
However, the molecular mechanisms responsible for steroid-induced diabetes remain largely …

BACKGROUND & AIMS: The expression levels of microRNA-29 (miR-29) family members (miR-29a,
miR-29b, miR-29c, here denoted collectively as miR-29a-c) are increased in livers …

Objective Celastrol was recently identified as a potential novel treatment for obesity. However,
the effect of Celastrol on nonalcoholic fatty liver disease (NAFLD) remains elusive. The …

Because of the mass and functions in metabolism, skeletal muscle is one of the major organs
regulating whole body metabolic homeostasis. SIRT6, a histone deacetylase, has been …

Human patatin‐like phospholipase domain‐containing 3 (PNPLA3) is associated with increased
liver fat content and liver injury. Here, we show that nutritional status regulates PNPLA3 …