Neuronal and non‐neuronal modulation of sympathetic neurovascular transmission

H Macarthur, GH Wilken, TC Westfall… - Acta …, 2011 - Wiley Online Library
Noradrenaline, neuropeptide Y and adenosine triphosphate are co‐stored in, and co‐released
from, sympathetic nerves. Each transmitter modulates its own release as well as the …

Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs.

…, MR Johnson, B Subramaniam, GH Wilken… - Molecular …, 1993 - ASPET
Cannabimimetic compounds, such as delta 9-tetrahydrocannabinol (delta 9-THC), evoke
analgesia in addition to other behavioral responses in humans and animals. The cannabinoid …

Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor

AC Howlett, TM Champion, GH Wilken… - Neuropharmacology, 1990 - Elsevier
The recent preparation of the enantiomers of 11-OH-Δ 8 -tetrahydrocannabinol-dimethylheptyl
(THC-DMH), recrystallized to absolute enantiomeric purity, has made it possible to …

Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2 …

JP Meschler, DM Kraichely, GH Wilken… - Biochemical …, 2000 - Elsevier
Two subtypes of cannabinoid receptors are currently recognized, CB 1 , found in brain and
neuronal cells, and CB 2 , found in spleen and immune cells. We have characterized 1-(2-…

Cannabinoid receptor binding and agonist activity of amides and esters of arachidonic acid.

…, D Boring, MR Johnson, DM Evans, GH Wilken… - Molecular …, 1994 - ASPET
The cannabinoid receptor in brain (CB1) specifically binds delta 9-tetrahydrocannabinol, the
predominant central nervous system-active component of marijuana. An eicosanoid found …

Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies

AC Howlett, C Song, BA Berglund, GH Wilken… - Molecular …, 1998 - ASPET
The mechanism by which CB 1 cannabinoid receptors are coupled to the G i /G o class of G
proteins was studied. A peptide representing the juxtamembrane carboxyl terminus robustly …

Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: correlation with preserved …

H Macarthur, DM Couri, GH Wilken… - Critical care …, 2003 - journals.lww.com
Objectives We have shown previously that inactivation of catecholamines by superoxide
anions contributes to the loss of vascular reactivity to norepinephrine and the subsequent …

Oxidative stress attenuates NO-induced modulation of sympathetic neurotransmission in the mesenteric arterial bed of spontaneously hypertensive rats

…, TC Westfall, GH Wilken - American Journal of …, 2008 - journals.physiology.org
Current evidence suggests that hyperactivity of the sympathetic nervous system and endothelial
dysfunction are important factors in the development and maintenance of hypertension. …

Structure-activity relationships defining the ACD-tricyclic cannabinoids: cannabinoid receptor binding and analgesic activity.

…, GM Milne, MR Johnson, GH Wilken… - Drug design and …, 1995 - europepmc.org
Previous studies of the structure-activity relationships (SAR) for binding of a series of AC-bicyclic
cannabinoid structures to the cannabinoid receptors in rat brain (believed to comprise …

Regulation of adenylate cyclase by cannabinoid drugs: insights based on thermodynamic studies

AC Howlett, DK Scott, GH Wilken - Biochemical pharmacology, 1989 - Elsevier
The abilities of lipophilic cannabinoid drugs to regulate adenylate cyclase activity in
neuroblastoma cell membranes were analyzed by thermodynamic studies. Arrhenius plots of …