User profiles for G. J. Kilpatrick

Gavin Kilpatrick

GJK Pharma
Verified email at gjkpharma.co.uk
Cited by 9344

[HTML][HTML] Remimazolam: non-clinical and clinical profile of a new sedative/anesthetic agent

GJ Kilpatrick - Frontiers in pharmacology, 2021 - frontiersin.org
A program to identify novel intravenous sedatives with a short and predictable duration of
action was initiated in the late 1990’s by Glaxo Wellcome. The program focussed on the …

Morphine‐6‐glucuronide: Actions and mechanisms

GJ Kilpatrick, TW Smith - Medicinal research reviews, 2005 - Wiley Online Library
Morphine‐6‐glucuronide (M6G) appears to show equivalent analgesia to morphine but to
have a superior side‐effect profile in terms of reduced liability to induce nausea and vomiting …

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

GJ Kilpatrick, BJ Jones, MB Tyers - Nature, 1987 - nature.com
Functional serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into three
subtypes: 5-HT 1 ,-like, 5-HT 2 and 5-HT 3 , (ref. 1). Brain binding sites have been identified for …

Molecular biology of the CRH receptors—in the mood

FM Dautzenberg, GJ Kilpatrick, RL Hauger, JL Moreau - Peptides, 2001 - Elsevier
Dysfunctioning of corticotropin-releasing hormone (CRH) and its receptors (CRH 1 and
CRH 2 ) has been linked to the development of stress-related disorders, such as mood and …

Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress

…, JL Moreau, JR Martin, GJ Kilpatrick… - Proceedings of the …, 1997 - National Acad Sciences
Orphanin FQ (OFQ, Nociceptin) is a recently discovered 17-amino acid neuropeptide that is
structurally related to the opioid peptides but does not bind opioid receptors. OFQ has been …

CNS 7056: a novel ultra–short-acting benzodiazepine

GJ Kilpatrick, MS McIntyre, RF Cox, JA Stafford… - …, 2007 - pubs.asahq.org
Background: A new benzodiazepine derivative, CNS 7056, has been developed to permit a
superior sedative profile to current agents, ie, more predictable fast onset, short duration of …

Histamine H3 receptors modulate the release of [3H]-acetylcholine from slices of rat entorhinal cortex: evidence for the possible existence of H3 receptor subtypes.

JI Clapham, GJ Kilpatrick - British journal of pharmacology, 1992 - ncbi.nlm.nih.gov
The effect of agents which interact with the histamine H3 receptor on potassium-stimulated
tritium release from slices of rat entorhinal cortex preloaded with [3H]-choline is described. …

A placebo-and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS …

LJ Antonik, DR Goldwater, GJ Kilpatrick… - Anesthesia & …, 2012 - journals.lww.com
Kilpatrick has approved the final manuscript. … Kilpatrick was an employee of PAION at the
time of conduct of the … Kilpatrick GJ, McIntyre MS, Cox RF, Stafford JA, Pacofsky GJ, Lovell GG, …

Development of a radioligand binding assay for 5-HT4 receptors in guinea-pig and rat brain.

CJ Grossman, GJ Kilpatrick… - British journal of …, 1993 - ncbi.nlm.nih.gov
The 5-HT4 receptor antagonist, GR113808, has been radiolabelled to a high specific activity
with tritium. 2. Characterization of specific [3H]-GR113808 binding in homogenates of …

5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret.

GA Higgins, GJ Kilpatrick, KT Bunce… - British Journal of …, 1989 - ncbi.nlm.nih.gov
The purpose of the present study was to identify and investigate the role of 5-hydroxytryptamine3
(5-HT3) receptors in the area postrema in the control of cisplatin-induced emesis in the …