Acute nociceptive pain is caused by the direct action of a noxious stimulus on pain-sensitive
nerve endings, whereas inflammatory pain (both acute and chronic) arises from the actions …

The rate of action potential firing in nociceptors is a major determinant of the intensity of pain.
Possible modulators of action potential firing include the HCN ion channels, which …

Positive allosteric modulators of α7 nicotinic acetylcholine receptors (nAChRs) have attracted
considerable interest as potential tools for the treatment of neurological and psychiatric …

Pain perception has evolved as a warning mechanism to alert organisms to tissue damage
and dangerous environments 1 , 2 . In humans, however, undesirable, excessive or chronic …

Conventional nicotinic acetylcholine receptor (nAChR) agonists, such as acetylcholine, act
at an extracellular “orthosteric” binding site located at the interface between two adjacent …

The generation of human sensory neurons by directed differentiation of pluripotent stem cells
opens new opportunities for investigating the biology of pain. The inability to generate this …

This study examined ratings of perceived exertion (RPE) and electro-myography (EMG)
during resistance exercise in recreational and novice lifters. Fourteen novice (age= 21.5+/-1.5 …

Previous studies have shown that hyperpolarisation-activated cyclic nucleotide-gated (HCN)–2
ion channels regulate the firing frequency of nociceptive sensory neurons and thus play …

The efficacy and safety of 0.025% capsaicin cream were evaluated when it was used as the
only symptomatic therapy in patients with osteoarthritis (OA) pain. Patients (113) received …

Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have
attracted considerable interest as a novel area of therapeutic drug discovery. Two types of α7-…