The four major classes of protease enzymes1-4 (aspartic, serine, cysteine, and metallo)
selectively catalyze the hydrolysis of polypeptide bonds. Their control over protein synthesis, …

This review describes the clinical status (based on available information) of experimental
drugs that inhibit enzymes called proteases, or more precisely a sub-class of proteases called …

Cyclic peptides that are potent regulators of biological processes are rapidly emerging as
important mechanistic probes and drug leads. Nature clearly uses macrocycles to, constrain …

… trityl resin (substitution value = 0.96 mmol/g) and subsequently cleaved from the solid
support with 95% TFA, 2.5% triisopropylsilane, and 2.5% water (15 ml/g resin) for 1 h at room …

… (∼1.0 mmol/g) and Rink-amide MBHA resin (∼0.70 mmol/g) encouraging intermolecular …
resin (Tentagel S RAM 0.25 mmol/g) 34 significantly improved the yield and purity of the …

… Extracted material was collected and centrifuged at 10,000 × g for 30 min (4 C). The
supernatant was concentrated with an Ultrafree 15 Biomax 5K cutoff centrifugal filter (Millipore) in …

… Female Wistar rats (250 to 300 g) were fasted and given water only for 12 hours prior to all
experiments. Animals were anesthetized by intraperitoneal injection of zolazepam (25 mg/kg -…

… We also chose to mimic a “superagonist” of the G protein-coupled receptor known as ORL-1
based on the native ligand nociceptin(1–17), a peptide hormone important in sensory …

Inhibitors of proteolytic enzymes (proteases) are emerging as prospective treatments for
diseases such as AIDS and viral infections, cancers, inflammatory disorders, and Alzheimer's …

G protein-coupled receptors (GPCRs) are seven transmembrane helical bundle proteins (Figure
1) found on the surface of all cells. 1-3 They mediate cellular responses to a diverse …