Specific tyrosine kinase inhibitors (TKIs) are rapidly developing clinical tools applied for the
inhibition of malignant cell growth and metastasis formation. Most of these newly developed …

Protein kinases are pivotal regulators of cell signaling that modulate each other's functions
and activities through site-specific phosphorylation events. These key regulatory …

Tyrosine kinase inhibitors (TKIs) are promising new agents for specific inhibition of
malignant cell growth and metastasis formation. Because most of the TKIs have to reach an …

Background and purpose: ABC multidrug transporters (MDR‐ABC proteins) cause multiple
drug resistance in cancer and may be involved in the decreased anti‐cancer efficiency and …

Members of the human protein kinase superfamily are the major regulatory enzymes involved
in the activity control of eukaryotic signal transduction pathways. As protein kinases reside …

Protein kinases play important roles in tumor development and progression. A variety of
members of this family of signal transduction enzymes serve as targets for therapeutic …

… g (1.00 mmol) 4-(3-chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-ol was refluxed
in 20 mL acetonitrile with 0.26 g (1.10 mmol) N-BOC-3-propyl-bromide and 0.15 g (… , 0.25 g (…

Iressa (ZD1839, Gefitinib), used in clinics to treat non–small cell lung cancer patients, is a
tyrosine kinase receptor inhibitor that leads to specific decoupling of epidermal growth factor …

… We have shown previously that TT-232 acts trough seven-pass transmembrane somatostatin
receptors to induce G 1 cell cycle arrest (5). This antiproliferative effect is mediated by the …

Objective We previously demonstrated that somatostatin (SOM) released from the activated
peripheral terminals of capsaicin‐sensitive primary sensory neurons inhibits acute …