Alzheimer’s disease is characterized by the progressive accumulation of extracellular deposits
of the amyloid β-peptide (Aβ) and intraneuronal aggregates of the microtubule associated …

… (van Echten-Deckert et al., unpublished observation) and induced apoptosis [84] in cerebellar
neurons. In addition, its accumulation was accompanied by a down-regulation of serine …

Lipids are essential structural and functional components of the central nervous system (CNS).
Sphingolipids are ubiquitous membrane components which were discovered in the brain …

… Gerhild van Echten-Deckert Gerhild van Echten-Deckert … Blood was collected in 1 10
volume of acid citrate dextrose as anticoagulant and centrifuged for 10 min at 150 × g at room …

… Gerhild van Echten-Deckert … Defatted glass plates were each coated with a mixture of 30
ml of double-distilled water, 0.8 g of Na 2 B 4 O 7 ·10H 2 O, and 14 g of Silica gel G 60 and were …

… Gerhild van Echten-Deckert Gerhild van Echten-Deckert … The Profftella genome (464,857
bp, 24% G + C), which consists of a circular chromosome (459,399 bp) and a small plasmid (…

Dihydroceramide desaturase is responsible for the introduction of the 4,5-trans double bond
into ceramide. Here, we describe the localization of this enzyme in the endoplasmic …

… Hagen N, Hans M, Hartmann D, Swandulla D, van Echten-Deckert G. Sphingosine-1-phosphate
links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated …

… Gerhild van Echten-Deckert Gerhild van Echten-Deckert … major regulators of early steps in
cell cycle progression, eg re-entry of quiescent cells into the cell cycle and start of G 1 phase ( …

We have recently reported that the bioactive lipid sphingosine-1-phosphate (S1P), usually
signaling proliferation and anti-apoptosis induces neuronal death when generated by …