User profiles for Geoffrey W. Abbott
Geoffrey W. AbbottUniversity of California, Irvine Verified email at uci.edu Cited by 9858 |
[HTML][HTML] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
A novel potassium channel gene has been cloned, characterized, and associated with
cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral …
cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral …
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
…, M Kennedy, E Henckaerts, K Bonham, GW Abbott… - Nature, 2008 - nature.com
The functional heart is comprised of distinct mesoderm-derived lineages including
cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo …
cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo …
A common polymorphism associated with antibiotic-induced cardiac arrhythmia
Drug-induced long QT syndrome (LQTS) is a prevalent disorder of uncertain etiology that
predisposes to sudden death. KCNE2 encodes MinK-related peptide 1 (MiRP1), a subunit of …
predisposes to sudden death. KCNE2 encodes MinK-related peptide 1 (MiRP1), a subunit of …
[HTML][HTML] MiRP2 forms potassium channels in skeletal muscle with Kv3. 4 and is associated with periodic paralysis
GW Abbott, MH Butler, S Bendahhou, MC Dalakas… - Cell, 2001 - cell.com
The subthreshold, voltage-gated potassium channel of skeletal muscle is shown to contain
MinK-related peptide 2 (MiRP2) and the pore-forming subunit Kv3.4. MiRP2-Kv3.4 channels …
MinK-related peptide 2 (MiRP2) and the pore-forming subunit Kv3.4. MiRP2-Kv3.4 channels …
The MinK-related peptides
ZA McCrossan, GW Abbott - Neuropharmacology, 2004 - Elsevier
Voltage-gated potassium (Kv) channels mediate rapid, selective diffusion of K + ions through
the plasma membrane, controlling cell excitability, secretion and signal transduction. KCNE …
the plasma membrane, controlling cell excitability, secretion and signal transduction. KCNE …
Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis
…, W Koba, E Fine, DJ Lerner, N Carrasco, GW Abbott - Nature medicine, 2009 - nature.com
Thyroid dysfunction is a global health concern, causing defects including neurodevelopmental
disorders, dwarfism and cardiac arrhythmia. Here, we show that the potassium channel …
disorders, dwarfism and cardiac arrhythmia. Here, we show that the potassium channel …
[HTML][HTML] The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion
Genes in the KCNE family encode single transmembrane domain ancillary subunits that co-assemble
with voltage-gated potassium (Kv) channel α subunits to alter their function. …
with voltage-gated potassium (Kv) channel α subunits to alter their function. …
[HTML][HTML] Biology of the KCNQ1 potassium channel
GW Abbott - New Journal of Science, 2014 - hindawi.com
Ion channels are essential for basic cellular function and for processes including sensory
perception and intercellular communication in multicellular organisms. Voltage-gated …
perception and intercellular communication in multicellular organisms. Voltage-gated …
The envelope protein of SARS‐CoV‐2 increases intra‐Golgi pH and forms a cation channel that is regulated by pH
Key points We report a novel method for the transient expression of SARS‐CoV‐2 envelope
(E) protein in intracellular organelles and the plasma membrane of mammalian cells and …
(E) protein in intracellular organelles and the plasma membrane of mammalian cells and …
[HTML][HTML] Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study
T Krogh-Madsen, GW Abbott… - PLoS computational …, 2012 - journals.plos.org
Atrial fibrillation, a common cardiac arrhythmia, often progresses unfavourably: in patients
with long-term atrial fibrillation, fibrillatory episodes are typically of increased duration and …
with long-term atrial fibrillation, fibrillatory episodes are typically of increased duration and …