[PDF][PDF] cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation
G Bhave, W Zhu, H Wang, DJ Brasier, GS Oxford… - Neuron, 2002 - cell.com
The capsaicin receptor, VR1 (also known as TRPV1), is a ligand-gated ion channel expressed
on nociceptive sensory neurons that responds to noxious thermal and chemical stimuli. …
on nociceptive sensory neurons that responds to noxious thermal and chemical stimuli. …
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
…, H Wang, DJ Brasier, GS Oxford… - Proceedings of the …, 2003 - National Acad Sciences
Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the …
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the …
The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons
PA Koplas, RL Rosenberg, GS Oxford - Journal of Neuroscience, 1997 - Soc Neuroscience
Capsaicin (Cap) is a pungent extract of theCapsicum pepper family, which activates nociceptive
primary sensory neurons. Inward current and membrane potential responses of cultured …
primary sensory neurons. Inward current and membrane potential responses of cultured …
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex
The use of N-type voltage-gated calcium channel (CaV2.2) blockers to treat pain is limited
by many physiological side effects. Here we report that inflammatory and neuropathic …
by many physiological side effects. Here we report that inflammatory and neuropathic …
Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1
W Zhu, GS Oxford - Molecular and Cellular Neuroscience, 2007 - Elsevier
Nerve growth factor (NGF) induces an acute sensitization of nociceptive DRG neurons, in
part, through sensitization of the capsaicin receptor TRPV1 via the high affinity trkA receptor. …
part, through sensitization of the capsaicin receptor TRPV1 via the high affinity trkA receptor. …
[HTML][HTML] Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein
FD Smith, GS Oxford, SL Milgram - Journal of Biological Chemistry, 1999 - ASBMB
Signaling through D2 class dopamine receptors is crucial to correct brain development and
function, and dysfunction of this system is implicated in major neurological disorders such as …
function, and dysfunction of this system is implicated in major neurological disorders such as …
[HTML][HTML] From the cover: protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
…, W Zhu, H Wang, DJ Brasier, GS Oxford… - Proceedings of the …, 2003 - ncbi.nlm.nih.gov
Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the …
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the …
Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines
EV Kuzhikandathil, W Yu, GS Oxford - Molecular and Cellular …, 1998 - Elsevier
The molecular mechanisms coupling the D3 dopamine receptor to downstream effectors
have neither been well defined nor well characterized. Here we examine the coupling of the …
have neither been well defined nor well characterized. Here we examine the coupling of the …
Classic D1 dopamine receptor AntagonistR-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly …
EV Kuzhikandathil, GS Oxford - Molecular pharmacology, 2002 - ASPET
R-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
(SCH23390) is a widely used, highly selective antagonist of D1 dopamine receptors. …
(SCH23390) is a widely used, highly selective antagonist of D1 dopamine receptors. …
Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation
…, N Morozova, PM Blumberg, GS Oxford - Journal of …, 2001 - Soc Neuroscience
The recently cloned vanilloid receptor subtype 1 (VR1) is a ligand-gated channel that is
activated by capsaicin, protons, and heat. We have attempted to develop a dominant negative …
activated by capsaicin, protons, and heat. We have attempted to develop a dominant negative …