NK cells recognize and kill human glioblastoma cells with stem cell-like properties

R Castriconi, A Daga, A Dondero, G Zona… - The Journal of …, 2009 - journals.aai.org
In this study, cancer cells were isolated from tumor specimens of nine glioblastoma patients.
Glioblastoma cells, cultured under suitable culture conditions, displayed markers typical of …

[HTML][HTML] Neurological manifestations of severe SARS-CoV-2 infection: potential mechanisms and implications of individualized mechanical ventilation settings

…, I Brunetti, P Anania, P Fiaschi, G Zona… - Frontiers in …, 2020 - frontiersin.org
In December 2019, an outbreak of illness caused by a novel coronavirus (2019-nCoV,
subsequently renamed SARS-CoV-2) was reported in Wuhan, China. Coronavirus disease 2019 (…

Octreotide-resistant acromegaly: challenges and solutions

…, F Nista, F Cocchiara, M Boschetti, G Zona… - … and Clinical Risk …, 2020 - Taylor & Francis
Acromegaly is a rare and severe disease caused by an increased and autonomous secretion
of growth hormone (GH), thus resulting in high circulating levels of insulin-like growth …

The role of external ventricular drainage for the management of posterior cranial fossa tumours: a systematic review

…, A Prior, M Ceraudo, DC Rossi, G Zona… - Neurosurgical …, 2021 - Springer
Posterior cranial fossa tumours frequently develop hydrocephalus as first presentation in up
to 80% of paediatric patients and 21.4% of adults, although it resolves after tumour removal …

Comparative analysis of DNA repair in stem and nonstem glioma cell cultures

…, A Zunino, A Poggi, E Cappelli, G Zona… - Molecular cancer …, 2009 - AACR
Angiogenesis of capillary endothelial cells includes at least four sequential cellular responses:
digestion of basement membrane, migration, proliferation, and differentiation. To study …

Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt

…, A Parodi, R Sirito, M Massollo, C Marini, G Zona… - Cell Cycle, 2013 - Taylor & Francis
Cancer stem cell theory postulates that a small population of tumor-initiating cells is responsible
for the development, progression and recurrence of several malignancies, including …

Expression of CXC chemokine receptors 1–5 and their ligands in human glioma tissues: role of CXCR4 and SDF1 in glioma cell proliferation and migration

…, A Daga, C Porcile, JL Ravetti, G Zona… - Neurochemistry …, 2006 - Elsevier
Chemokines have been involved in cellular processes associated to malignant transformation
such as proliferation, migration and angiogenesis. The expression of five CXC chemokine …

[HTML][HTML] Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors

…, F Barbieri, RE Favoni, ML Casto, G Zona… - Journal of biological …, 2009 - ASBMB
Because a subpopulation of cancer stem cells (tumor-initiating cells, TICs) is believed to be
responsible for the development, progression, and recurrence of many tumors, we evaluated …

Expression of the chemokine receptor CXCR4 and its ligand stromal cell‐derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro

…, P Piccioli, P Pirani, JL Ravetti, G Zona… - Annals of the New …, 2002 - Wiley Online Library
Chemokines are a family of proteins that chemoattract and activate cells by interacting with
specific receptors on the surface of their targets. They are grouped into four classes based on …

Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity

…, A Bajetto, R Würth, A Daga, P Fiaschi, G Zona… - Toxicology, 2013 - Elsevier
Cancer stem cells (CSCs) or tumor initiating cells (TICs) drive glioblastoma (GBM) development,
invasiveness and drug resistance. Distinct molecular pathways might regulate CSC …