Multidrug resistance (MDR) is a phenomenon by which cancer cells evade the cytotoxic
effects of chemotherapeutic agents. It may occur through different mechanisms, but it often …

Background Like other steroid hormones, vitamin D elicits both transcriptional events and
rapid non genomic effects. Vitamin D receptor (VDR) localization and mechanisms of VDR-…

Background and purpose: Artemisinin is an antimalarial drug exerting pleiotropic effects, such
as the inhibition of the transcription factor nuclear factor‐kappa B and of the sarcoplasmic/…

Glioblastoma Multiforme (GBM) is an incurable malignancy. GBM patients have a short life
expectancy despite aggressive therapeutic approaches based on surgical resection followed …

The antimalarial action of methylene blue (MB) was first noted by Paul Ehrlich in the late
19th century. Although it has only sporadically been adopted as a serviceable drug, the …

Nitric oxide (NO) is a free radical involved in the regulation of many cell functions and in the
expression of several diseases. We have found that the antimalarial and antiinflammatory …

Platelet-activating factor (PAF), but not its deacetylated and biologically inactive metabolite
lyso-PAF, in a dose dependent-manner (0.1 to 10 nM), induces human endothelial cells (EC) …

The novel COVID-19 pandemic is affecting the world’s population differently: mostly in the
presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal …

We recently described the mitochondrial localization and import of the vitamin D receptor (VDR)
in actively proliferating HaCaT cells for the first time, but its role in the organelle remains …

How anti-neoplastic agents induce MDR (multidrug resistance) in cancer cells and the role
of GSH (glutathione) in the activation of pumps such as the MRPs (MDR-associated proteins) …