The psychoactive constituent of cannabis, Δ 9 -tetrahydrocannabinol, produces in humans
subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous …

The potent analgesic effects of cannabis-like drugs 1 , 2 , 3 , 4 and the presence of CB1-type
cannabinoid receptors in pain-processing areas of the brain and spinal cord 5 , 6 indicate …

Palmitoylethanolamide (PEA), the naturally occurring amide of palmitic acid and ethanolamine,
reduces pain and inflammation through an as-yet-uncharacterized mechanism. Here, we …

Severe pain remains a major area of unmet medical need. Here we report that agonists of
the nuclear receptor PPAR-α (peroxisome proliferator-activated receptor-α) suppress pain …

Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic
acid, is an endogenous lipid that modulates pain and inflammation. Although the anti-…

The endogenous fatty acid ethanolamide, palmitylethanolamide, alleviated, in a dose-dependent
manner, pain behaviors elicited in mice by injections of formalin (5%, intraplantar), …

Smoking marijuana or administration of its main active constituent, Δ 9 -tetrahydrocannabinol
(Δ 9 -THC), may exert potent dilating effects on human airways 1 , 2 , 3 , 4 . But the …

The endocannabinoids anandamide and 2-arachidonoyglycerol (2-AG) may contribute to
the regulation of mood and emotion. In this study, we investigated the impact of the …

The human gut is a composite anaerobic environment with a large, diverse and dynamic
enteric microbiota, represented by more than 100 trillion microorganisms, including at least …

Fatty acid amide hydrolase (FAAH) is an intracellular serine hydrolase that catalyzes the
cleavage of bioactive fatty acid ethanolamides, such as the endogenous cannabinoid agonist …