We report that oxytocin (OT), a primitive neurohypophyseal hormone, hitherto thought solely
to modulate lactation and social bonding, is a direct regulator of bone mass. Deletion of OT …

Various cinnammoyl-based structures were synthesized and tested in enzyme assays as
inhibitors of the HIV-1 integrase (IN). The majority of compounds were designed as …

During space flight, severe losses of bone mass are observed. Both bone formation and
resorption are probably involved, but their relative importance remains unclear. The purpose of …

Pyrrolyl aryl sulfones (PASs) have been recently reported as a new class of human
immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) inhibitors acting at the non-…

The synthesis, pharmacological evaluation, and structure−activity relationships (SARs) of a
series of novel pyrroloquinoxalines and heteroaromatic-related derivatives are described. …

Quinoxalinylethylpyridylthioureas (QXPTs) represent a new class of human immunodeficiency
virus type 1 (HIV-1) non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) whose …

Background/Objectives Calcific aortic valvular disease (CAVD) is an actively regulated process
characterized by the activation of specific osteogenic signaling pathways and apoptosis. …

Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis
steatohepatitis, fibrosis, and cirrhosis to hepatocellular carcinoma. Forty-four per cent of all …

Novel N,N-disubstituted indol-3-ylglyoxylamides (1−56), bearing different combinations of
substituents R 1 −R 5 , were synthesized and evaluated as ligands of the translocator protein (…

Molecular modeling analysis of compounds belonging to the recently published series of
dihydro-alkoxy-benzyl-oxopyrimidines (DABOs), such as S-DABOs and DATNOs, gave support …