User profiles for Giovanni Maga

Giovanni Maga

IGM CNR
Verified email at igm.cnr.it
Cited by 15052

Proliferating cell nuclear antigen (PCNA): a dancer with many partners

G Maga, U Hubscher - Journal of cell science, 2003 - journals.biologists.com
Proliferating cell nuclear antigen (PCNA) was originally characterised as a DNA sliding
clamp for replicative DNA polymerases and as an essential component of the eukaryotic …

Eukaryotic DNA polymerases

U Hübscher, G Maga, S Spadari - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract Any living cell is faced with the fundamental task of keeping the genome intact in
order to develop in an organized manner, to function in a complex environment, to divide at …

[HTML][HTML] A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping

M Romano, A Ruggiero, F Squeglia, G Maga, R Berisio - Cells, 2020 - mdpi.com
The current coronavirus disease-2019 (COVID-19) pandemic is due to the novel coronavirus
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …

[HTML][HTML] Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol

…, F Carafoli, P Perucca, L Bianchi, G Maga… - Journal of Biological …, 2001 - ASBMB
Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a natural phytoalexin found in grapes and
wine, which shows antioxidant and antiproliferative activities. In this study we have …

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

G Maga, G Villani, E Crespan, U Wimmer, E Ferrari… - Nature, 2007 - nature.com
Specialized DNA polymerases (DNA pols) are required for lesion bypass in human cells 1 .
Auxiliary factors have an important, but so far poorly understood, role. Here we analyse the …

[HTML][HTML] The RNA helicase, nucleotide 5′-triphosphatase, and RNA 5′-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a …

D Benarroch, B Selisko, GA Locatelli, G Maga… - Virology, 2004 - Elsevier
The nonstructural protein 3 (NS3) of Dengue virus (DV) is a multifunctional enzyme carrying
activities involved in viral RNA replication and capping: helicase, nucleoside 5′-…

Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide

…, C Ciaprini, A Sinistro, G Maga… - Journal of medicinal …, 2006 - ACS Publications
Molecular modeling studies and an updated highly predictive 3-D QSAR model led to the
discovery of exceptionally potent indolyl aryl sulfones (IASs) characterized by the presence of …

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide

…, A Brancale, F Piscitelli, V Gatti, G Maga… - Journal of medicinal …, 2011 - ACS Publications
New indolylarylsulfone derivatives bearing cyclic substituents at indole-2-carboxamide linked
through a methylene/ethylene spacer were potent inhibitors of the WT HIV-1 replication in …

Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase δ by the concerted action of replication protein A, proliferating cell …

G Maga, G Villani, V Tillement… - Proceedings of the …, 2001 - National Acad Sciences
DNA polymerase (pol) δ is essential for both leading and lagging strand DNA synthesis
during chromosomal replication in eukaryotes. Pol δ has been implicated in the Okazaki …

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

…, M Zazzi, A Garbelli, G Maga… - Proceedings of the …, 2016 - National Acad Sciences
Targeting a host factor essential for the replication of different viruses but not for the cells offers
a higher genetic barrier to the development of resistance, may simplify therapy regimens …