Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, …

Throughout evolution, numerous proteins have been convergently recruited into the
venoms of various animals, including centipedes, cephalopods, cone snails, fish, insects (several …

Introduction: An extraordinarily diverse range of animals have evolved venoms for predation,
defence, or competitor deterrence. The major components of most venoms are peptides …

Spider venoms are an incredibly rich source of disulfide-rich insecticidal peptides that have
been tuned over millions of years to target a wide range of receptors and ion channels in the …

Spiders are the most successful venomous animals and the most abundant terrestrial predators.
Their remarkable success is due in large part to their ingenious exploitation of silk and …

Molecular toxinology research was initially driven by an interest in the small subset of animal
toxins that are lethal to humans. However, the realization that many venomous creatures …

Voltage-gated sodium (Na v ) channels initiate action potentials in most neurons, including
primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non-…

The remarkable potency and pharmacological diversity of animal venoms has made them
an increasingly valuable source of lead molecules for drug and insecticide discovery. …

Voltage-gated sodium (Na V ) channels play a central role in the propagation of action potentials
in excitable cells in both humans and insects. Many venomous animals have therefore …

NMR spectroscopy is a powerful tool for studying the structure, function and dynamics of
biological macromolecules. However, non‐spectroscopists often find NMR theory daunting and …