User profiles for Gregory R. J. Thatcher

Gregory Thatcher

Vahlteich Chair & Professor of Medicinal Chemistry
Verified email at uic.edu
Cited by 8186

Potential mechanisms of estrogen quinone carcinogenesis

JL Bolton, GRJ Thatcher - Chemical research in toxicology, 2008 - ACS Publications
There is a clear association between the excessive exposure to estrogens and the development
of cancer in hormone-sensitive tissues (breast, endometrium). It has become clear that …

[HTML][HTML] Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors

M Siklos, M BenAissa, GRJ Thatcher - Acta Pharmaceutica Sinica B, 2015 - Elsevier
Cysteine proteases continue to provide validated targets for treatment of human diseases.
In neurodegenerative disorders, multiple cysteine proteases provide targets for enzyme …

Nitrates and NO release: contemporary aspects in biological and medicinal chemistry

GRJ Thatcher, AC Nicolescu, BM Bennett… - Free Radical Biology and …, 2004 - Elsevier
Nitroglycerine has been used clinically in the treatment of angina for 130 years, yet important
details on the mechanism of action, biotransformation, and the associated phenomenon of …

Design of SARS-CoV-2 PLpro inhibitors for COVID-19 antiviral therapy leveraging binding cooperativity

…, O Dubrovskyi, L Rong, GRJ Thatcher… - Journal of medicinal …, 2021 - ACS Publications
Antiviral agents that complement vaccination are urgently needed to end the COVID-19
pandemic. The SARS-CoV-2 papain-like protease (PLpro), one of only two essential cysteine …

Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity

…, PA Petukhov, JL Bolton, GRJ Thatcher - Journal of Medicinal …, 2007 - ACS Publications
The regulation of estrogenic and antiestrogenic effects of selective estrogen receptor
modulators (SERMs) is thought to underlie their clinical use. Most SERMs are polyaromatic …

[HTML][HTML] Dimethyl fumarate inhibits the nuclear factor κB pathway in breast cancer cells by covalent modification of p65 protein

…, G Georgieva, EN Thayer, GRJ Thatcher… - Journal of Biological …, 2016 - ASBMB
In breast tumors, activation of the nuclear factor κB (NFκB) pathway promotes survival,
migration, invasion, angiogenesis, stem cell-like properties, and resistance to therapy—all …

GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway

…, S Sreevalsan, S Anand, GRJ Thatcher… - Molecular Cancer …, 2011 - AACR
Ethyl 2-((2,3-bis(nitrooxy)propyl)disulfanyl)benzoate (GT-094) is a novel nitric oxide (NO)
chimera containing an nonsteroidal anti-inflammatory drug (NSAID) and NO moieties and also …

Cortical proteins associated with cognitive resilience in community-dwelling older persons

…, AP Wingo, TS Wingo, N Kearns, GRJ Thatcher… - JAMA …, 2020 - jamanetwork.com
Importance Identifying genes and proteins for cognitive resilience (ie, targets that may be
associated with slowing or preventing cognitive decline regardless of the presence, number, or …

[HTML][HTML] Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo

…, Y Wang, NC Collins, MB Aissa, GRJ Thatcher… - Journal of Biological …, 2014 - ASBMB
Previous data demonstrate that bexarotene (Bex), retinoid X receptor (RXR) agonist, reduces
soluble and insoluble amyloid-β (Aβ) in Alzheimer disease (AD)-transgenic mice either by …

Phosphonates as mimics of phosphate biomolecules: ab initio calculations on tetrahedral ground states and pentacoordinate intermediates for phosphoryl transfer

GRJ Thatcher, AS Campbell - The Journal of Organic Chemistry, 1993 - ACS Publications
The use of phosphonates as analogs of phosphate biomolecules was explored using ab initio
SCF calculations at the 3-21G (*) and 3-21+ G (*) levels. Fully optimized geometries were …