Intensive lifestyle changes have been shown to regress atherosclerosis, improve cardiovascular
risk profiles, and decrease angina pectoris and cardiac events. We evaluated the …

Although cognitive dysfunction manifested by severe memory and attention deficits has been
reported in up to 70% of cancer patients undergoing chemotherapy, the mechanisms of this …

The recent discovery of the family of Toll‐like receptors has vastly expanded our understanding
of the mechanisms by which the innate immune system recognizes and responds to a …

Fresh myelin, isolated from brainstems of adult rats, was incubated in the presence of Cu 2+
and H 2 O 2 . Electrophoretic analysis of the reisolated myelin membrane revealed a …

Toll‐like receptors (TLRs) are sentinels of the innate immune system that recognize an array
of exogenous and endogenous pathogenic molecules. The ligation of the receptors triggers …

The genotoxicity of reactive oxygen species (ROS) is well established. The underlying
mechanism involves oxidation of DNA by ROS. However, we have recently shown that hydrogen …

It is well established that mediators of peripheral inflammation are relayed to the brain and
elicit sickness behavior via neuroinflammatory agents that target neuronal substrates. In the …

Elimination of hydrogen sulfide from glutathione (GSH) converts a well known cellular
nucleophile to an electrophilic species, γ-glutamyldehydroalanylglycine (EdAG). We have found …

CNS inflammation is a sequela of a variety of neuropathological conditions resulting in extensive
tissue loss. Inflammation is mediated primarily by phagocytic cells, but the mechanisms …

Tumor suppressor gene BRCA1 is frequently mutated in familial breast and ovarian cancer.
BRCA1 plays pivotal roles in maintaining genomic stability by interacting with numerous …