Endothelial cell dysfunction and the pathobiology of atherosclerosis

MA Gimbrone Jr, G García-Cardeña - Circulation research, 2016 - Am Heart Assoc
Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease. Endothelial …

[HTML][HTML] Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1

G García-Cardeña, R Fan, DF Stern, J Liu… - Journal of Biological …, 1996 - ASBMB
The regulation of endothelial nitric oxide synthase (eNOS) by phosphorylation is poorly
understood. Here, we demonstrate that eNOS is tyrosine-phosphorylated in bovine aortic …

Biomechanical forces promote embryonic haematopoiesis

…, MW Lensch, MC Yoder, G García-Cardeña… - Nature, 2009 - nature.com
Biomechanical forces are emerging as critical regulators of embryogenesis, particularly in the
developing cardiovascular system 1 , 2 . After initiation of the heartbeat in vertebrates, cells …

Recent insights into the cellular biology of atherosclerosis

I Tabas, G García-Cardeña, GK Owens - Journal of Cell Biology, 2015 - rupress.org
Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at regions
of disturbed blood flow and is triggered by an interplay between endothelial dysfunction …

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

A Papapetropoulos, G García-Cardeña… - The Journal of …, 1997 - Am Soc Clin Investig
Vascular endothelial growth factor (VEGF) is a regulator of vasculogenesis and angiogenesis.
To investigate the role of nitric oxide (NO) in VEGF-induced proliferation and in vitro …

Dynamic activation of endothelial nitric oxide synthase by Hsp90

G García-Cardeña, R Fan, V Shah, R Sorrentino… - Nature, 1998 - nature.com
Heat-shock protein 90 (Hsp90) coordinates the trafficking and regulation of diverse signalling
proteins, but its precise role in regulating specific cellular targets is not known 1 , 2 . Here …

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and-resistant regions of human vasculature

…, RD Kamm, G García-Cardeña… - Proceedings of the …, 2004 - National Acad Sciences
Atherosclerotic lesion localization to regions of disturbed flow within certain arterial geometries,
in humans and experimental animals, suggests an important role for local hemodynamic …

[HTML][HTML] Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

…, MA Gimbrone Jr, G García-Cardeña - The Journal of …, 2006 - Am Soc Clin Investig
In the face of systemic risk factors, certain regions of the arterial vasculature remain relatively
resistant to the development of atherosclerotic lesions. The biomechanically distinct …

KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation

…, MA Gimbrone Jr, G García-Cardeña… - The Journal of …, 2004 - rupress.org
The vascular endothelium is a critical regulator of vascular function. Diverse stimuli such as
proinflammatory cytokines and hemodynamic forces modulate endothelial phenotype and …

Biomechanical activation of vascular endothelium as a determinant of its functional phenotype

G García-Cardeña, J Comander… - Proceedings of the …, 2001 - National Acad Sciences
One of the striking features of vascular endothelium, the single-cell-thick lining of the
cardiovascular system, is its phenotypic plasticity. Various pathophysiologic factors, such as …