Mechanisms of neurosteroid interactions with GABAA receptors
Neuroactive steroids have some of their most potent actions by augmenting the function of
GABA A receptors. Endogenous steroid actions on GABA A receptors may underlie important …
GABA A receptors. Endogenous steroid actions on GABA A receptors may underlie important …
Desensitization of mouse nicotinic acetylcholine receptor channels: a two-gate mechanism
A Auerbach, G Akk - The Journal of general physiology, 1998 - rupress.org
The rate constants of acetylcholine receptor channels (AChR) desensitization and recovery
were estimated from the durations and frequencies of clusters of single-channel currents. …
were estimated from the durations and frequencies of clusters of single-channel currents. …
The influence of the membrane on neurosteroid actions at GABAA receptors
Modern views of anesthetic neurosteroid interaction with the GABA A receptor conceptualize
steroid ligands interacting with a protein binding site on the receptor. It has generally been …
steroid ligands interacting with a protein binding site on the receptor. It has generally been …
Multiple non-equivalent interfaces mediate direct activation of GABAA receptors by propofol
…, J Henry Steinbach, AS Evers, G Akk - Current …, 2016 - ingentaconnect.com
Background: Propofol is a sedative agent that at clinical concentrations acts by allosterically
activating or potentiating the γ-aminobutyric acid type A (GABAA) receptor. Mutational, …
activating or potentiating the γ-aminobutyric acid type A (GABAA) receptor. Mutational, …
Pregnenolone sulfate block of GABAA receptors: mechanism and involvement of a residue in the M2 region of the α subunit
G Akk, J Bracamontes… - The Journal of …, 2001 - Wiley Online Library
1 Neurosteroids are produced in the brain, and can have rapid actions on membrane
channels of neurons. Pregnenolone sulfate (PS) is a sulfated neurosteroid which reduces the …
channels of neurons. Pregnenolone sulfate (PS) is a sulfated neurosteroid which reduces the …
Neurosteroid access to the GABAA receptor
G Akk, HJ Shu, C Wang, JH Steinbach… - Journal of …, 2005 - Soc Neuroscience
GABA A receptors are a pivotal inhibitory influence in the nervous system, and modulators of
the GABA A receptor are important anesthetics, sedatives, anticonvulsants, and anxiolytics. …
the GABA A receptor are important anesthetics, sedatives, anticonvulsants, and anxiolytics. …
[HTML][HTML] Maximum likelihood estimation of ion channel kinetics from macroscopic currents
LS Milescu, G Akk, F Sachs - Biophysical journal, 2005 - cell.com
We describe a maximum likelihood method for direct estimation of rate constants from
macroscopic ion channel data for kinetic models of arbitrary size and topology. The number of …
macroscopic ion channel data for kinetic models of arbitrary size and topology. The number of …
Modulation of GABAA receptor channel gating by pentobarbital
JH Steinbach, G Akk - The Journal of physiology, 2001 - Wiley Online Library
1 We have studied the kinetic properties of channel gating of recombinant α1β2γ2L GABA A
receptors transiently expressed in human embryonic kidney 293 cells, using the cell‐…
receptors transiently expressed in human embryonic kidney 293 cells, using the cell‐…
[HTML][HTML] Multiple functional neurosteroid binding sites on GABAA receptors
…, B Manion, WWL Cheng, DE Reichert, G Akk… - PLoS …, 2019 - journals.plos.org
Neurosteroids are endogenous modulators of neuronal excitability and nervous system
development and are being developed as anesthetic agents and treatments for psychiatric …
development and are being developed as anesthetic agents and treatments for psychiatric …
Activation and modulation of human α4β2 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid
P Li, J Ann, G Akk - Journal of neuroscience research, 2011 - Wiley Online Library
Neonicotinoids are synthetic, nicotine‐derived insecticides used for agricultural and
household pest control. Though highly effective at activating insect nicotinic receptors, many …
household pest control. Though highly effective at activating insect nicotinic receptors, many …