De‐racemization of enantiomers versus de‐epimerization of diastereomers—classification of dynamic kinetic asymmetric transformations (DYKAT)

J Steinreiber, K Faber, H Griengl - Chemistry–A European …, 2008 - Wiley Online Library
… enantiomeric diester I R I R and meso-isomer (I S I R ) mainly depends on the epimerization
rate of H S I R and H R I R (k 1 ) versus the anti-Kazlauskas acylation rate of H S I R (k 2 ). …

Oxidative biotransformations using oxygenases

…, WA Duetz, A Schmid, A de Raadt, H Griengl… - Current opinion in …, 2002 - Elsevier
… The volumetric productivity reached 0.45 g/l/h, which is slightly higher than that of the in vivo
… The volumetric productivity reached 0.20 g/l/h, representing the first synthetic application of …

The synthesis of chiral cyanohydrins by oxynitrilases

H Griengl, H Schwab, M Fechter - Trends in biotechnology, 2000 - cell.com
Enantiomerically pure cyanohydrins are important synthetic intermediates for pharmaceuticals
and agrochemicals. They are produced by enzyme-catalysed synthesis using oxynitrilases…

High-level intracellular expression of hydroxynitrile lyase from the tropical rubber TreeHevea brasiliensisin microbial hosts

…, J Lückl, H Griengl, SD Kohlwein, H Schwab - Protein expression and …, 1997 - Elsevier
… with a limiting glycerol feed of 160 g/h for 24 h. Hnl production was induced by replacing
glycerol 1% BSA for 1 h. Polyclonal antiserum against Hnl from H. brasiliensis (8) was used at a …

[PDF][PDF] A biocatalytic Henry reaction-the hydroxynitrile lyase from Hevea brasiliensis also catalyzes nitroaldol reactions

…, K Waich, W Skranc, D Mink, H Griengl - … EDITION IN ENGLISH …, 2006 - researchgate.net
… required to perform nitroaldol reactions and reach acceptable yields within 48 h. Regarding
the scope of the reaction with respect to the carbonyl acceptor, several representative …

[PDF][PDF] Biocatalytic Friedel–Crafts Alkylation Using Non‐natural Cofactors

…, P Remler, H Schwab, H Griengl… - Angewandte …, 2009 - graz.elsevierpure.com
… We observed quantitative conversion in less than 2 days (average reaction time 24 h; Table
1). The chemical synthesis of SAM analogues results in approximately 1: 1 diastereomeric …

Relation between depression and anxiety in dystonic patients: implications for clinical management

…, A Wimmer, T Wenzel, P Birner, H Griengl… - Depression and …, 2002 - Wiley Online Library
Past clinical research has identified depression as the most common psychiatric disorder
associated with cervical dystonia (CD). The purpose of our study is to document different …

Threonine aldolases—an emerging tool for organic synthesis

…, F van Assema, M Wolberg, D Mink, H Griengl - Tetrahedron, 2007 - Elsevier
… as in a higher analytical yield (79%) after 4 h. Rising the temperature to 20 and 30 C resulted
in a … No similar effects were detected for lTA at temperatures below 40 C and after 2 h the …

Potential and capabilities of hydroxynitrile lyases as biocatalysts in the chemical industry

…, W Skranc, C Schuster, H Griengl - Applied microbiology and …, 2007 - Springer
The application of hydroxynitrile lyases (HNLs) as catalysts for the stereoselective condensation
of HCN with carbonyl compounds has been reported as early as 1908. This enzymatic C…

[HTML][HTML] Molecular Cloning of the Full-length cDNA of (S)-Hydroxynitrile Lyase from Hevea brasiliensis: FUNCTIONAL EXPRESSION IN ESCHERICHIA COLI AND …

…, M Hayn, H Griengl, SD Kohlwein, H Schwab - Journal of Biological …, 1996 - ASBMB
… 8-10 h, plates were overlaid with a nylon filter soaked in 10 mM isopropyl-1-thio-β-D-galactopyranoside,
and expression from the lac promoter was induced by incubation for 3 h. Filters …