Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism

…, EM Hagelin, F Lauritzen, H Attramadal… - Cerebral …, 2014 - academic.oup.com
The G-protein-coupled lactate receptor, GPR81 (HCA1), is known to promote lipid storage
in adipocytes by downregulating cAMP levels. Here, we show that GPR81 is also present in …

[HTML][HTML] Regulation and intracellular trafficking pathways of the endothelin receptors

…, C Sandberg, B Bremnes, H Attramadal - Journal of Biological …, 2000 - ASBMB
The effects of endothelin (ET) are mediated via the G protein-coupled receptors ET A and
ET B . However, the mechanisms of ET receptor desensitization, internalization, and …

Myocardial expression of CC-and CXC-chemokines and their receptors in human end-stage heart failure

…, G Christensen, SS Frøland, H Attramadal… - Cardiovascular …, 2000 - academic.oup.com
Objectives: Chemokines regulate several biological processes, such as chemotaxis, collagen
turnover, angiogenesis and apoptosis. Based on the persistent immune activation with …

Connective tissue growth factor—a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats

…, Y Andersson, T Attramadal, H Attramadal - Journal of molecular and …, 2004 - Elsevier
The pathophysiologic mechanisms of myocardial remodeling in heart failure (HF) remain
poorly understood. Using differential mRNA display of myocardial tissue from rats with ischemic …

Elevated levels of activin A in heart failure: potential role in myocardial remodeling

…, E Øie, G Florholmen, B Halvorsen, H Attramadal… - Circulation, 2004 - Am Heart Assoc
Background— Although modulation of inflammatory processes has been suggested as a new
treatment modality in heart failure (HF), our knowledge about abnormalities in the cytokine …

The lactate receptor, G‐protein‐coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

…, K Andersson, A Gjedde, H Attramadal… - Journal of …, 2015 - Wiley Online Library
We have proposed that lactate is a “volume transmitter” in the brain and underpinned this by
showing that the lactate receptor, G‐protein‐coupled receptor 81 (GPR81, also known as …

NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective

…, SH Nymo, A Rashidi, IK Ohm, H Attramadal… - Biochemical and …, 2016 - Elsevier
Background The innate immune receptor NLRP3 recognizes tissue damage and initiates
inflammatory processes through formation multiprotein complexes with the adaptor protein …

β-adrenergic receptor kinase-2 and β-arrestin-2 as mediators of odorant-induced desensitization

…, JL Arriza, DE Jaworsky, FF Borisy, H Attramadal… - Science, 1993 - science.org
β-Adrenergic receptor kinase (βARK) and β-arrestin function in the homologous or agonist-activated
desensitization of G protein-coupled receptors. The isoforms βARK-2 and β-arrestin-…

[HTML][HTML] Connective tissue growth factor (CCN2) is a matricellular preproprotein controlled by proteolytic activation

…, EMV Hagelin, MQ Dong, H Attramadal - Journal of Biological …, 2018 - ASBMB
Connective tissue growth factor (CTGF; now often referred to as CCN2) is a secreted protein
predominantly expressed during development, in various pathological conditions that …

[HTML][HTML] Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

H Attramadal, JL Arriza, C Aoki, TM Dawson… - Journal of Biological …, 1992 - Elsevier
Homologous or agonist-specific desensitization of beta 2-adrenergic receptors (beta 2AR)
is mediated by the beta-adrenergic receptor kinase (beta ARK) which specifically …