Biomonitoring of exposure to chemical warfare agents: a review
D Noort, HP Benschop, RM Black - Toxicology and applied pharmacology, 2002 - Elsevier
In this report an overview of the methods currently available for detection of exposure to a
number of chemical warfare agents (CWA), ie, sulfur mustard, lewisite and nerve agents, is …
number of chemical warfare agents (CWA), ie, sulfur mustard, lewisite and nerve agents, is …
Nerve agent stereoisomers: analysis, isolation and toxicology
HP Benschop, LPA De Jong - Accounts of Chemical Research, 1988 - ACS Publications
Nerve agents are lethal chemical warfare agents, which were developed a few years before
World War II. 1 They were selected for their extreme and acute mam-malian toxicity via …
World War II. 1 They were selected for their extreme and acute mam-malian toxicity via …
Retrospective detection of exposure to organophosphorus anti-cholinesterases: mass spectrometric analysis of phosphylated human butyrylcholinesterase
…, MJ Van der Schans, HP Benschop… - Chemical research in …, 2002 - ACS Publications
In this paper a novel and general procedure is presented for detection of organophosphate-inhibited
human butyrylcholinesterase (HuBuChE), which is based on electrospray tandem …
human butyrylcholinesterase (HuBuChE), which is based on electrospray tandem …
New method for retrospective detection of exposure to organophosphorus anticholinesterases: application to alleged sarin victims of Japanese terrorists
M Polhuijs, JP Langenberg, HP Benschop - Toxicology and applied …, 1997 - Elsevier
With regard to detection of exposure to anticholinesterase, the presently used methods have
the disadvantage that they cannot detect either low-level exposures with certainty or the …
the disadvantage that they cannot detect either low-level exposures with certainty or the …
Alkylation of human serum albumin by sulfur mustard in vitro and in vivo: mass spectrometric analysis of a cysteine adduct as a sensitive biomarker of exposure
…, AG Hulst, LPA de Jong, HP Benschop - Chemical research in …, 1999 - ACS Publications
To develop a mass spectrometric assay for the detection of sulfur mustard adducts with
human serum albumin, the following steps were performed: quantitation of the binding of the …
human serum albumin, the following steps were performed: quantitation of the binding of the …
Synthesis, characterization, and quantitation of the major adducts formed between sulfur mustard and DNA of calf thymus and human blood
…, RA Baan, LPA de Jong, HP Benschop - Chemical research in …, 1994 - ACS Publications
As part of a program to develop methods for verification of alleged exposure to sulfur mustard,
we synthesized and characterized the adducts most likely formed by alkylation of DNA …
we synthesized and characterized the adducts most likely formed by alkylation of DNA …
Quantitative analysis of O-isopropyl methylphosphonic acid in serum samples of Japanese citizens allegedly exposed to sarin: estimation of internal dosage
…, DHJM Platenburg, M Polhuijs, HP Benschop - Archives of …, 1998 - Springer
A convenient and rapid micro-anion exchange liquid chromatography (LC) tandem electrospray
mass spectrometry (MS) procedure was developed for quantitative analysis in serum of …
mass spectrometry (MS) procedure was developed for quantitative analysis in serum of …
Toxicokinetics of the nerve agent (±)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration
…, H van der Wiel, JP Langenberg, HP Benschop - Toxicology and applied …, 2003 - Elsevier
In continuation of our investigations on the toxicokinetics of the volatile nerve agents C(±)P(±)-soman
and (±)-sarin, we now report on the toxicokinetics of the rather nonvolatile agent (±)…
and (±)-sarin, we now report on the toxicokinetics of the rather nonvolatile agent (±)…
Verification of exposure to sulfur mustard in two casualties of the Iran-Iraq conflict
HP Benschop, GP van der Schans… - Journal of analytical …, 1997 - academic.oup.com
… de Jong, and HP Benschop. Synthesis, characterization and quantification of the major
adducts formed between sulfur mustard and DNA of calf thymus and human blood. Chem. …
adducts formed between sulfur mustard and DNA of calf thymus and human blood. Chem. …
Toxicokinetics of soman: species variation and stereospecificity in elimination pathways
HP Benschop, LPA De Jong - Neuroscience & Biobehavioral Reviews, 1991 - Elsevier
Blood levels of the four stereoisomers of the nerve agent C(±)P(±)-soman were analyzed
gas chromatographically in anaesthetized, artificially respirated and atropinized rats, guinea …
gas chromatographically in anaesthetized, artificially respirated and atropinized rats, guinea …