Recommendations for buprenorphine and methadone therapy in opioid use disorder: a European consensus

…, N Szerman, R Littlewood, F Alam, H Alho… - Expert opinion on …, 2017 - Taylor & Francis
… and reaches peak concentration in 1–4 h, with onset of action after 30–45 min and effects
observed for 8–12 h at low doses (2 mg) and 48–72 h at higher doses (16 or 32 mg) [Citation38…

[HTML][HTML] Craving in opioid use disorder: from neurobiology to clinical practice

J Kakko, H Alho, A Baldacchino, R Molina… - Frontiers in …, 2019 - frontiersin.org
Opioid use disorder (OUD) is a major public health issue that has reached epidemic levels
in some parts of the world. It is a chronic and complex neurobiological disease associated …

New biomarker evidence of oxidative DNA damage in patients with non‐insulin‐dependent diabetes mellitus

…, V Rantalaiho, O Wirta, A Pasternack, H Alho - FEBS …, 1997 - Wiley Online Library
… from 24 h urine samples of 81 NIDDM patients 9 years after the initial diagnosis and of 100
non-diabetic control subjects matched for age and gender. The total 24 h urinary excretion of …

Biomarker evidence of DNA oxidation in lung cancer patients: association of urinary 8‐hydroxy‐2′‐deoxyguanosine excretion with radiotherapy, chemotherapy, and …

…, K Uchida, T Osawa, MM Nieminen, H Alho… - FEBS …, 1997 - Wiley Online Library
… Urine samples were obtained from each individual at the first morning voiding after
approximately 6 hours' collection (generally 0 h to 6 h), and stored at −80C until analyses. …

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.

M Favaron, H Manev, H Alho… - Proceedings of the …, 1988 - National Acad Sciences
Using a sensitive histofluorescence staining method that allows for a quantitation of neuronal
death, we compared the protective effects of gangliosides (a group of naturally occurring …

Expression of peripheral-type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: relationship to cell proliferation

…, P Helén, P Sallinen, T Harjuntausta, H Helin, H Alho - Cancer research, 1995 - AACR
… samples were incubated for 16 to 22 h either with a polyclonal (1:500) or a monoclonal (1:50…
Briefly, the sections were hybridized at 42ÂCfor 18 h with 1 x 7 IO7cpm/ml of the probe, …

Abuse liability of buprenorphine–naloxone tablets in untreated IV drug users

H Alho, D Sinclair, E Vuori, A Holopainen - Drug and alcohol dependence, 2007 - Elsevier
Buprenorphine (Subutex ® ) is widely abused in Finland. A combination of buprenorphine
plus naloxone (Suboxone ® ) has been available since late 2004, permitting a comparison of …

Low plasma antioxidant activity is associated with high lesion volume and neurological impairment in stroke

…, M Jehkonen, P Dastidar, G Molnár, H Alho - Stroke, 2000 - Am Heart Assoc
Background and Purpose—Oxidative stress is probably involved in neuronal damage induced
by ischemia-reperfusion. The purpose of this study was to assess the role of antioxidant …

Mesolimbic dopamine release is linked to symptom severity in pathological gambling

…, MM Hirvonen, P Piepponen, E Arponen, H Alho… - Neuroimage, 2012 - Elsevier
… function, intoxicated or recent substance use (within 36 h prior to the PET study), and
consumption of coffee/tea within the last 12 h prior to PET study. In the psychiatric interviews, none …

A randomized, multicentre, open-label, comparative trial of disulfiram, naltrexone and acamprosate in the treatment of alcohol dependence

…, M Salaspuro, H Ahtinen, H Alho - Alcohol & …, 2008 - academic.oup.com
Aim: To compare the effects in alcohol-dependent patients of three pharmacotherapies,
disulfiram (DIS), naltrexone (NTX), and acamprosate (ACA), when used with a brief manual-…