The odd sibling: features of β3-adrenoceptor pharmacology

H Cernecka, C Sand, MC Michel - Molecular pharmacology, 2014 - ASPET
β 3 -Adrenoceptor agonists have recently been introduced for the treatment of overactive
urinary bladder syndrome. Their target, the β 3 -adrenoceptor, was discovered much later than …

[HTML][HTML] The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease

PR Dale, H Cernecka, M Schmidt, MR Dowling… - Current opinion in …, 2014 - Elsevier
… work from these investigators reported that relaxation responses to the β 3 -selective
agonist KUC-7322 were also weaker against carbachol than against the other responses (Cernecka

[HTML][HTML] Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists

…, J Frederick, H Cernecka, H Liu… - The Journal of …, 2024 - Am Soc Clin Investig
Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …

[HTML][HTML] Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP

…, E Hallscheidt, J Eichhorst, B Wiesner, H Černecká… - Cells, 2020 - mdpi.com
… The CDK18 forms were immunoprecipitated 48 h later with anti-FLAG-coupled magnetic
beads (Sigma-Aldrich; 1 h, 4 C). The beads were washed and incubated with individual spot-…

Ramipril restores PPARβ/δ and PPARγ expressions and reduces cardiac NADPH oxidase but fails to restore cardiac function and accompanied myosin heavy chain …

H Cernecka, G Doka, J Srankova, L Pivackova… - European Journal of …, 2016 - Elsevier
We hypothesized that peroxisome proliferator-activated receptors (PPARs) might be
involved in a complex protective action of ACE inhibitors (ACEi) in anthracyclines-induced …

Specificity evaluation of antibodies against human β3-adrenoceptors

H Cernecka, P Ochodnicky, WH Lamers… - … archives of pharmacology, 2012 - Springer
β 3 -Adrenoceptors are a promising drug target for the treatment of urinary bladder dysfunction,
but knowledge about their expression at the protein level and their functional role is …

[HTML][HTML] β3-Adrenoceptor-mediated relaxation of rat and human urinary bladder: roles of BKCa channels and Rho kinase

H Cernecka, K Kersten, H Maarsingh… - Naunyn-schmiedeberg's …, 2015 - Springer
… Bands were visualized after 1.5 h of incubation with horseradish-peroxidase-conjugated
donkey anti-goat (antibody 705-035-003; Jackson ImmunoResearch; dilution 1:3000) or donkey …

Enalaprilat increases PPARβ/δ expression, without influence on PPARα and PPARγ, and modulate cardiac function in sub-acute model of daunorubicin-induced …

H Cernecka, K Ochodnicka-Mackovicova… - European journal of …, 2013 - Elsevier
… For this purpose, Wistar rats were administered with daunorubicin (ip, 3 mg/kg, in 48 h
intervals) or co-administered with daunorubicine and enalaprilat (ip, 5 mg/kg in 12 h intervals). …

Glucose and blood pressure lowering effects of Pycnogenol® are inefficient to prevent prolongation of QT interval in experimental diabetic cardiomyopathy

S Jankyova, J Kmecova, H Cernecka… - … -Research and Practice, 2012 - Elsevier
… Animals were kept under a stable regimen of 12 h light/12 h’ darkness. All procedures
involving the use of experimental animals were approved by the State Veterinary and Food …

Pioglitazone, a PPARγ agonist, provides comparable protection to angiotensin converting enzyme inhibitor ramipril against adriamycin nephropathy in rat

P Ochodnicky, L Mesarosova, H Cernecka… - European Journal of …, 2014 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) agonists have been shown to
ameliorate diabetic nephropathy, but much less are known about their effects in non-diabetic …