Structural genomics projects in Japan
S Yokoyama, H Hirota, T Kigawa, T Yabuki… - nature structural …, 2000 - nature.com
Two major structural genomics projects exist in Japan. The oldest, the RIKEN Structural
Genomics Initiative, has two major goals: to determine bacterial, mammalian, and plant protein …
Genomics Initiative, has two major goals: to determine bacterial, mammalian, and plant protein …
[HTML][HTML] Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress
H Hirota, J Chen, UAK Betz, K Rajewsky, Y Gu, J Ross… - Cell, 1999 - cell.com
Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart
failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine …
failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine …
Germline gain-of-function mutations in RAF1 cause Noonan syndrome
…, M Matsushima, K Mizuno, M Tokuyama, H Hirota… - Nature …, 2007 - nature.com
… Adult zebrafish (Danio rerio) were maintained at 28.5 C under 14-h light/10-h dark cycle
conditions. Embryos from natural crosses were collected a few minutes after spawning and …
conditions. Embryos from natural crosses were collected a few minutes after spawning and …
Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.
H Hirota, K Yoshida, T Kishimoto… - Proceedings of the …, 1995 - National Acad Sciences
… minigenes of human (h) IL-6 and membrane-anchored hIL-6R under promoters constitutively
switched on inimmune (murine major histocompatibility complex class I H-2Ld promoter) (…
switched on inimmune (murine major histocompatibility complex class I H-2Ld promoter) (…
Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma.
H Hirota, H Kiyama, T Kishimoto, T Taga - The Journal of experimental …, 1996 - rupress.org
In this study we aimed to examine a role for interleukin 6 (IL-6) and its receptor (IL-6R) in
peripheral nerve regeneration in vivo. We first observed that cultured mouse embryonic dorsal …
peripheral nerve regeneration in vivo. We first observed that cultured mouse embryonic dorsal …
Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.
…, S Wada, DM Findlay, TJ Martin, H Hirota… - The Journal of …, 1995 - rupress.org
… Likewise, normal bone and bone marrow were formed in mice overexpressing human IL-6R
(Hirota, H., unpublished observation). In cocultures of spleen cells from transgenic mice …
(Hirota, H., unpublished observation). In cocultures of spleen cells from transgenic mice …
AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress
…, T Kuroda, M Hori, I Kawase, H Hirota - … and cellular biology, 2005 - Am Soc Microbiol
… 0.5 mM of AICAR and 1 h later exposed to hypoxia for 30 h. Viability of cardiomyocytes was
… 0.5 mM of AICAR and 1 h later exposed to hypoxia for 30 h. Injury of cardiomyocytes was …
… 0.5 mM of AICAR and 1 h later exposed to hypoxia for 30 h. Injury of cardiomyocytes was …
[PDF][PDF] Notoamides AD: prenylated indole alkaloids isolated from a marine-derived fungus, Aspergillus sp.
H Kato, T Yoshida, T Tokue, Y Nojiri, H Hirota, T Ohta… - 2007 - kanazawa-u.repo.nii.ac.jp
… NOE experiment of 3 in acetone-d6 revealed a correlation between H-11 and H-17, … broad
NH (H-1) signal in 1. In addition, the differences of chemical shifts were observed for H-25 (δ …
NH (H-1) signal in 1. In addition, the differences of chemical shifts were observed for H-25 (δ …
Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation …
…, T Osugi, M Izumi, Y Oshima, Y Nakaoka, H Hirota… - Circulation, 2001 - Am Heart Assoc
… of H/R-induced ROS evaluated by 2′,7′-dichlorofluorescin diacetate fluorescence. To
assess whether ROS are really involved in H/… and caSTAT3 significantly decreased H/R-induced …
assess whether ROS are really involved in H/… and caSTAT3 significantly decreased H/R-induced …
VI. Genome structure and cognitive map of Williams syndrome
JR Korenberg, XN Chen, H Hirota, Z Lai… - Journal of cognitive …, 2000 - direct.mit.edu
Williams syndrome (WMS) is a most compelling model of human cognition, of human genome
organization, and of evolution. Due to a deletion in chromosome band 7q11.23, subjects …
organization, and of evolution. Due to a deletion in chromosome band 7q11.23, subjects …