User profiles for Han Kiat Ho
 | Han Kiat HoNational University of Singapore Verified email at nus.edu.sg Cited by 6659 |
Carbon nanotubes for delivery of small molecule drugs
In the realm of drug delivery, carbon nanotubes (CNTs) have gained tremendous attention
as promising nanocarriers, owing to their distinct characteristics, such as high surface area, …
as promising nanocarriers, owing to their distinct characteristics, such as high surface area, …
Nanomaterial scaffolds for stem cell proliferation and differentiation in tissue engineering
Tissue engineering is a clinically driven field and has emerged as a potential alternative to
organ transplantation. The cornerstone of successful tissue engineering rests upon two …
organ transplantation. The cornerstone of successful tissue engineering rests upon two …
Nanoparticles' interactions with vasculature in diseases
The ever-growing use of inorganic nanoparticles (NPs) in biomedicine provides an exciting
approach to develop novel imaging and drug delivery systems, owing to the ease with which …
approach to develop novel imaging and drug delivery systems, owing to the ease with which …
[HTML][HTML] Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models
Introduction Mesenchymal stem cell-conditioned medium (MSC-CM) has been shown to
have protective effects against various cellular-injury models. This mechanism of protection, …
have protective effects against various cellular-injury models. This mechanism of protection, …
Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness
While most cancer nanomedicine is designed to eliminate cancer, the nanomaterial per se
can lead to the formation of micrometre-sized gaps in the blood vessel endothelial walls. …
can lead to the formation of micrometre-sized gaps in the blood vessel endothelial walls. …
Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents …
BACKGROUND/AIMS: FGFR4, a member of the fibroblast growth factor receptor family, has
been recently associated with progression of melanoma, breast and head and neck …
been recently associated with progression of melanoma, breast and head and neck …
[HTML][HTML] Engineering tumoral vascular leakiness with gold nanoparticles
Delivering cancer therapeutics to tumors necessitates their escape from the surrounding
blood vessels. Tumor vasculatures are not always sufficiently leaky. Herein, we engineer …
blood vessels. Tumor vasculatures are not always sufficiently leaky. Herein, we engineer …
Metabolism‐related pharmacokinetic drug− drug interactions with tyrosine kinase inhibitors: current understanding, challenges and recommendations
Drug−drug interactions ( DDIs ) occur when a patient's response to the drug is modified by
administration or co‐exposure to another drug. The main cytochrome P 450 ( CYP ) enzyme, …
administration or co‐exposure to another drug. The main cytochrome P 450 ( CYP ) enzyme, …
All roads lead to the liver: metal nanoparticles and their implications for liver health
Metal nanoparticles (NPs) are frequently encountered in daily life, and concerns have been
raised about their toxicity and safety. Among which, they naturally accumulate in the liver …
raised about their toxicity and safety. Among which, they naturally accumulate in the liver …
Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib
…, JW Oh, LS New, MD Wahlin, SD Nelson, HK Ho… - Molecular …, 2010 - ASPET
Fatalities stemming from hepatotoxicity associated with the clinical use of lapatinib (Tykerb),
an oral dual tyrosine kinase inhibitor (ErbB-1 and ErbB-2) used in the treatment of metastatic …
an oral dual tyrosine kinase inhibitor (ErbB-1 and ErbB-2) used in the treatment of metastatic …