Retinitis pigmentosa, caused predominantly by mutations in photoreceptor genes, currently
lacks comprehensive treatment. We discover that retinal microglia contribute non‐cell …

Considerable progress has been made in testing stem cell–derived retinal pigment epithelium
(RPE) as a potential therapy for age-related macular degeneration (AMD). However, the …

γ-AMINOBUTYRIC acid (GABA) is the main inhibitory neurotransmitter in the central nervous
system. Two classes of GABA receptors (GABA A and GABA B ) have been identified. …

Mutations in the X-linked retinitis pigmentosa GTPase regulator (RPGR) gene are a major
cause of retinitis pigmentosa, a blinding retinal disease resulting from photoreceptor …

Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene account for >70% of X-linked
retinitis pigmentosa (XLRP) and 15–20% of all inherited retinal degeneration. Gene …

Purpose.: The aryl hydrocarbon receptor (AHR) is a ligand-activated nuclear receptor that
regulates cellular response to environmental signals, including UV and blue wavelength light. …

Photochemical switches represent a powerful method for improving pharmacological
therapies and controlling cellular physiology. Here we report the photoregulation of GABA A …

This study reports pharmacological and physiological effects of cis- and trans-(3-aminocyclopentanyl)butylphosphinic
acid (cis- and trans-3-ACPBPA). These compounds are …

purpose. To examine retinal function in female Long-Evans rats with streptozotocin (STZ)-induced
diabetes. methods. Hyperglycemia was induced by IV injection of STZ, and ERG …

The polycistronic miR-183/96/182 cluster is preferentially and abundantly expressed in
terminally differentiating sensory epithelia. To clarify its roles in the terminal differentiation of …