[PDF][PDF] Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.

H Safayhi, T Mack, J Sabieraj, MI Anazodo… - … of Pharmacology and …, 1992 - Citeseer
Isomers (a-and fi-) of boswellic acids (BAs), 11-keto-3-BA and In Contrast to the redox type 5-LO
inhibitor nordihydroguaiaretic their acetyl derivatives were isolated from the gum resin …

A novel biologically active seleno-organic compound—II: activity of PZ 51 in relation to Glutathione Peroxidase

A Wendel, M Fausel, H Safayhi, G Tiegs… - Biochemical …, 1984 - Elsevier
The anti-inflammatory compound 2-phenyl-1,2-benzoisoselenazol-3(2H)-on (PZ 51)
catalysed GSSG formation from GSH in the presence of hydroperoxides in an NADPH/GSSG …

Effects of gum resin of Boswellia serrata in patients with chronic colitis

…, P Malhotra, S Gupta, R Lüdtke, H Safayhi… - Planta …, 2001 - thieme-connect.com
Patients studied here suffered from chronic colitis characterized by vague lower abdominal
pain, bleeding per rectum with diarrhoea and palpable tender descending and sigmoid colon…

Inhibition by boswellic acids of human leukocyte elastase

H Safayhi, B Rall, ER Sailer, HPT Ammon - Journal of Pharmacology and …, 1997 - ASPET
Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of
frankincense, block leukotriene biosynthesis and exert potent anti-inflammatory effects. …

Acetyl-11-keto-beta-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity.

…, RF Hoernlein, HP Ammon, H Safayhi - British journal of …, 1996 - ncbi.nlm.nih.gov
5-Lipoxygenase (5-LOX) products from endogenous arachidonic acid in ionophore-stimulated
peritoneal polymorphonuclear leukocytes (PMNL) and from exogenous substrate (20 …

Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid.

H Safayhi, ER Sailer, HP Ammon - Molecular pharmacology, 1995 - ASPET
The formation of 5-lipoxygenase (EC 1.13.11.34) products from endogenous substrate by
intact rat neutrophilic granulocytes and from exogenous arachidonic acid by rat granulocyte …

Acetyl-11-keto-β-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis

…, SE Boden, S Schweizer, H Safayhi… - International journal of …, 2001 - Springer
The gum resin extract from Boswellia serrata (H15), an herbal product, was recently shown
to have positive therapeutic effects in inflammatory bowel disease (IBD). However, the …

Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues

…, E Bayer, HPT Ammon, H Safayhi - Journal of Natural …, 2000 - ACS Publications
Pentacyclic triterpenes from the 11-keto-boswellic acid series were identified as the active
principal ingredients of Boswellia resin, inhibiting the key enzyme of leukotriene biosynthesis, …

Concentration-dependent potentiating and inhibitory effects of boswellia extracts on 5-lipoxygenase product formation instimulated PMNL

H Safayhi, SE Boden, S Schweizer… - Planta medica, 2000 - thieme-connect.com
Preparations from the gum of Boswellia spec. have been used in the traditional medicine for
the treatment of inflammatory diseases. Extracts from B. serrata gum were shown to inhibit …

Characterization of an acetyl‐11‐keto‐β‐boswellic acid and arachidonate‐binding regulatory site of 5‐lipoxygenase using photoaffinity labeling

…, SE Boden, HPT Ammon, H Safayhi - European journal of …, 1998 - Wiley Online Library
AKBA (acetyl‐11‐keto‐β‐boswellic acid), a natural pentacyclic triterpene, is an orally active
leukotriene‐synthesis inhibitor, which acts by a 5‐lipoxygenase−directed, non‐redox, non‐…