Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia

…, BS Kahl, C Bello, HK Webb… - Blood, The Journal …, 2014 - ashpublications.org
In a phase 1 trial, idelalisib (GS-1101, CAL-101), a selective inhibitor of the lipid kinase
PI3Kδ, was evaluated in 54 patients with relapsed/refractory chronic lymphocytic leukemia (CLL) …

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

A Ueda, HK Hamadeh, HK Webb, Y Yamamoto… - Molecular …, 2002 - ASPET
Phenobarbital (PB) induces various gene encoding drug/steroid-metabolizing enzymes such
as cytochromes P450 (P450s) and transferases. Although the nuclear orphan constitutive …

Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-δ, as therapy for previously treated indolent non-Hodgkin lymphoma

…, S Peterman, Y Cho, HK Webb… - Blood, The Journal …, 2014 - ashpublications.org
Idelalisib (GS-1101, CAL-101), an oral inhibitor of phosphatidylinositol 3-kinase-δ, was
evaluated in a phase I study in 64 patients with relapsed indolent non-Hodgkin lymphoma (iNHL)…

Pharmacokinetics and pharmacodynamics of AR9281, an inhibitor of soluble epoxide hydrolase, in single‐and multiple‐dose studies in healthy human subjects

…, SK Anandan, R Gless, HK Webb - The Journal of …, 2012 - Wiley Online Library
AR9281, a potent and selective inhibitor of soluble epoxide hydrolase (s‐EH), is in clinical
development targeting hypertension and type 2 diabetes. The safety, pharmacokinetics, and …

[HTML][HTML] Clinical safety and activity in a phase 1 study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110δ, in patients with relapsed or …

…, S Coutre, B Lannutti, NA Giese, RG Ulrich, HK Webb… - Blood, 2010 - Elsevier
Abstract 1777 Introduction: The class I phosphatidylinositol 3-kinases (PI3Ks) regulate
cellular functions relevant to oncogenesis. Expression of the PI3K p110δ isoform (PI3Kδ) is …

Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia

…, D Chen, SK Anandan, R Gless, HK Webb… - … , and vascular biology, 2009 - Am Heart Assoc
Objective— Epoxyeicosatrienoic acids (EETs) have been shown to have antiinflammatory
effects and therefore may play a role in preventing vascular inflammatory and atherosclerotic …

Inhibiting TGF-β signaling restores immune surveillance in the SMA-560 glioma model

…, V Sriram, S Aulwurm, I Kerr, A Lam, HK Webb… - Neuro …, 2007 - academic.oup.com
Transforming growth factor-β (TGF-β) is a proinvasive and immunosuppressive cytokine that
plays a major role in the malignant phenotype of gliomas. One novel strategy of disabling …

CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110δ, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed …

…, SE Spurgeon, B Lannutti, NA Giese, HK Webb… - 2010 - ashpublications.org
Abstract 55 Introduction: The class I phosphatidylinositol 3-kinases (PI3Ks) regulate cellular
functions relevant to oncogenesis. Expression of the PI3K p110δ isoform (PI3Kδ) is …

Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension

…, SK Anandan, GM Rubanyi, HK Webb… - European journal of …, 2011 - Elsevier
Endothelial dysfunction is a hallmark of, and plays a pivotal role in the pathogenesis of
cardiometabolic diseases, including type II diabetes, obesity, and hypertension. It has been well …

Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor κB signaling

Y Liu, HK Webb, H Fukushima, J Micheli… - … of Pharmacology and …, 2012 - ASPET
Acute kidney injury is associated with a significant inflammatory response that has been the
target of renoprotection strategies. Epoxyeicosatrienoic acids (EETs) are anti-inflammatory …