Bisphosphonates are chemically stable analogs of inorganic pyrophosphate, which are
resistant to breakdown by enzymatic hydrolysis. The biological effects of bisphosphonates on …

Recently, advances have been made in understanding the molecular mechanisms by which
bisphosphonate drugs inhibit bone resorption. Studies with the macrophage-like cell line …

The exact mechanisms of action of antiresorptive bisphosphonate drugs remain unclear,
although they may inhibit bone resorption by mechanisms that can lead to osteoclast apoptosis. …

Osteoclasts are notoriously hard to study because of the difficulty in obtaining pure populations
of cells in large numbers for biochemical and molecular analyses. Unlike with other …

Recent studies have proposed that non-nitrogen-containing and nitrogen-containing
bisphosphonate drugs inhibit osteoclastic bone resorption by different molecular mechanisms. The …

The last decade has seen a tremendous advance in our understanding of bone biology. The
genes responsible for the majority of rare inherited bone disorders have been identified and …

O objetivo deste artigo é identificar e analisar as frames mobilizadas pelos movimentos
feministas para tratar da violência contra as mulheres, bem como discutir suas influências nas …

We report on a somaesthetic design workshop and the subsequent analytical work aiming
to demystify what is entailed in a non-dualistic design stance on embodied interaction and …

Introduction Bisphosphonates are the most widely used class of drug for inhibiting osteoclast-mediated
bone loss, but their effectiveness at preventing joint destruction in rheumatoid …

Volunteering benefits recipients, volunteers, communities, and society, while digital
technologies establish new opportunities for virtual volunteering. We describe how volunteers …