Germline mutations in a number of genes involved in the recombinational repair of DNA
double-strand breaks are associated with predisposition to breast and ovarian cancer. RAD51C …

The development of stem–cell gene therapy is hindered by the absence of repopulation assays
for primitive human hematopoietic cells. Current methods of gene transfer rely on in vitro …

Fanconi anemia (FA) is an autosomal recessive disorder characterized by cellular
hypersensitivity to DNA cross-linking agents and cancer predisposition. Recent evidence for the …

PALB2 was recently identified as a nuclear binding partner of BRCA2. Biallelic BRCA2
mutations cause Fanconi anemia subtype FA-D1 and predispose to childhood malignancies. We …

Hematopoietic cells are important targets for genetic modification with retroviral vectors.
Attempts at human gene therapy of stem cells have achieved limited success partly because of …

UVB radiation-induced signaling in mammalian cells involves two major pathways: one that
is initiated through the generation of DNA photoproducts in the nucleus and a second one …

Fanconi anemia (FA) is a rare chromosomal-instability disorder associated with a variety of
developmental abnormalities, bone marrow failure and predisposition to leukemia and other …

Seven Fanconi anemia–associated proteins (FANCA, FANCB, FANCC, FANCE, FANCF,
FANCG and FANCL) form a nuclear Fanconi anemia core complex that activates the …

Fanconi anemia is a rare recessive disorder characterized by genome instability, congenital
malformations, progressive bone marrow failure and predisposition to hematologic …

Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes and …