Wnt proteins are a family of secreted proteins that regulate many aspects of cell growth,
differentiation, function, and death. Considerable progress has been made in our understanding …

Interaction of the estrogen receptor/ligand complex with a DNA estrogen response element
is known to regulate gene transcription. In turn, specific conformations of the receptor-ligand …

Raloxifene, [2-(4-hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
hydrochloride (2), is representative of a class of compounds known as …

GSK‐3, a component of the canonical Wnt signaling pathway, is implicated in regulation of
bone mass. The effect of a small molecule GSK‐3 inhibitor was evaluated in pre‐osteoblasts …

For the first time, four well‐charac‐ terized compounds from four distinct chemical classes were
directly compared for efficacy and potency in bone, uteri, lipids, and adipose tissues in an …

Estrogen is a key regulatory hormone, which in addition to its role in reproduction, affects a
number of physiological systems, including the skeleton and cardiovascular system. The …

The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator which is
currently under clinical evaluation for the prevention and treatment of postmenopausal …

Estrogen or raloxifene (LY156758) prevent estrogen deficiency-induced bone loss in animals
and humans. We demonstrated in the rat that a 22% reduction in bone mineral density …

The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator (SERM)
which is currently under clinical evaluation for the prevention and treatment of …

Representative non-steroidal estrogens, from common environmental sources such as plants,
pesticides, surfactants, plastics, and animal health products, demonstrated an ability to …