Escape of Intracellular Shigella from Autophagy

M Ogawa, T Yoshimori, T Suzuki, H Sagara… - Science, 2005 - science.org
The degradation of undesirable cellular components or organelles, including invading microbes,
by autophagy is crucial for cell survival. Here, Shigella, an invasive bacteria, was found …

Architecture of ribonucleoprotein complexes in influenza A virus particles

T Noda, H Sagara, A Yen, A Takada, H Kida… - Nature, 2006 - nature.com
In viruses, as in eukaryotes, elaborate mechanisms have evolved to protect the genome and
to ensure its timely replication and reliable transmission to progeny. Influenza A viruses are …

[HTML][HTML] Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein

…, S Tanaka, Y Hara, S Koshikawa, H Sagara… - Nature …, 2016 - nature.com
Tardigrades, also known as water bears, are small aquatic animals. Some tardigrade
species tolerate almost complete dehydration and exhibit extraordinary tolerance to various …

Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP

T Noda, H Sagara, E Suzuki, A Takada, H Kida… - Journal of …, 2002 - Am Soc Microbiol
Using biochemical assays, it has been demonstrated that expression of Ebola virus VP40
alone in mammalian cells induced production of particles with a density similar to that of virions…

Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells

I Yana, H Sagara, S Takaki, K Takatsu… - Journal of cell …, 2007 - journals.biologists.com
The membrane-anchored matrix metalloproteinase MT1-MMP (also known as Mmp14) plays
a key role in the angiogenic process, but the mechanisms underlying its spatiotemporal …

Performance of collagen sponge as a 3-D scaffold for tooth-tissue engineering

Y Sumita, MJ Honda, T Ohara, S Tsuchiya, H Sagara… - Biomaterials, 2006 - Elsevier
Tooth structure can be regenerated by seeding dissociated tooth cells onto polyglycolic acid
fiber mesh, although the success rate of tooth production is low. The present study was …

[HTML][HTML] Assembly and Budding of Ebolavirus

…, Y Muramoto, K Fujii, A Takada, H Sagara… - PLoS …, 2006 - journals.plos.org
Ebolavirus is responsible for highly lethal hemorrhagic fever. Like all viruses, it must
reproduce its various components and assemble them in cells in order to reproduce infectious …

[HTML][HTML] Three-dimensional analysis of ribonucleoprotein complexes in influenza A virus

…, A Hirase, E Kawakami, A Miyazawa, H Sagara… - Nature …, 2012 - nature.com
The influenza A virus genome consists of eight single-stranded negative-sense RNA (vRNA)
segments. Although genome segmentation provides advantages such as genetic …

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

…, S Nakagawa, S Nagai, H Sagara… - Proceedings of the …, 2007 - National Acad Sciences
ACTH (ie, corticotropin) is the principal regulator of the hypothalamus–pituitary–adrenal
axis and stimulates steroidogenesis in the adrenal gland via the specific cell-surface …

Simultaneous tracking of capsid, tegument, and envelope protein localization in living cells infected with triply fluorescent herpes simplex virus 1

K Sugimoto, M Uema, H Sagara, M Tanaka… - Journal of …, 2008 - Am Soc Microbiol
We report here the construction of a triply fluorescent-tagged herpes simplex virus 1 (HSV-1)
expressing capsid protein VP26, tegument protein VP22, and envelope protein gB as …