It has previously been reported that a 3-(3-(piperazin-1-yl)propyl)indole series of 5-HT 1D
receptor ligands have pharmacokinetic advantages over the corresponding 3-(3-(piperidin-1-yl…

In pursuit of a GABA A α5-subtype-selective inverse agonist to enhance cognition, a series
of 6,7-dihydro-2-benzothiophen-4(5H)-ones has been identified as a novel class of GABA A …

Sphingolipids (SLs) are essential components of cellular membranes formed from the
condensation of l-serine and a long-chain acyl thioester. This first step is catalyzed by the pyridoxal…

A method has been devised to obtain heterocyclic ring systems suitable for use in drug design
and library design, with an emphasis on the selection of systems with good absorption, …

Schizophrenia is a mental illness for which there is still a great need for novel drug therapy.
Classical neuroleptics, which are presumed to act by antagonism of dopamine D2 receptors, …

The limonoid insect antifeedant azadirachtin (1) may be partially hydrogenated at the C22-C23
position and subsequently treated with an excess of sodium periodate and potassium …

Despite ITS SIDE-EFFECT profile and narrow thera-peutic window, Li’remains the treatment
of choice for bipolar disorder’,‘. However, the mechanism by which it attenuates the dramatic …

myo-Inositol monophosphatase (myo-inositol-1-phosphate phosphohydrolase, EC 3.1.3.25)
is an attractive target for mechanistic investigation due to its critical role in the …

The design, synthesis, and biological activity of a novel series of CCK-B receptor antagonists
(1) which incorporate a tetrazol-5-ylamino functionality attached to the phenyl ring of the …

A series of N 1 -arylsulfonyltryptamines were found to be potent ligands of the human serotonin
5-HT 6 receptor with the 5-methoxy-1-benzenesulfonyl analogue (19) having the highest …