Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease

HM Gao, J Jiang, B Wilson, W Zhang… - Journal of …, 2002 - Wiley Online Library
The etiology of sporadic Parkinson's disease (PD) remains unknown. Increasing evidence
has suggested a role for inflammation in the brain in the pathogenesis of PD. However, it has …

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

HM Gao, JS Hong - Trends in immunology, 2008 - cell.com
Neurodegenerative diseases are a group of chronic, progressive disorders characterized by
the gradual loss of neurons in discrete areas of the central nervous system (CNS). The …

Role of nitric oxide in inflammation‐mediated neurodegeneration

BIN Liu, HUIM GAO, JIZYUH WANG… - Annals of the New …, 2002 - Wiley Online Library
Increasing evidence has suggested that inflammation in the brain is closely associated with
the pathogenesis of several degenerative neurologic disorders, including Parkinson's …

Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons

HM Gao, JS Hong, W Zhang, B Liu - Journal of Neuroscience, 2002 - Soc Neuroscience
Increasing evidence has suggested an important role for environmental factors such as
exposure to pesticides in the pathogenesis of Parkinson's disease. In experimental animals the …

Neuroinflammation and oxidation/nitration of α-synuclein linked to dopaminergic neurodegeneration

HM Gao, PT Kotzbauer, K Uryu, S Leight… - Journal of …, 2008 - Soc Neuroscience
α-Synuclein (SYN) is the major component of Lewy bodies, the neuropathological hallmarks
of Parkinson's disease (PD). Missense mutations and multiplications of the SYN gene cause …

The effectiveness of problem-based learning on development of nursing students' critical thinking: A systematic review and meta-analysis

LN Kong, B Qin, Y Zhou, S Mou, HM Gao - International journal of nursing …, 2014 - Elsevier
Objectives The objective of this systematic review and meta-analysis was to estimate the
effectiveness of problem-based learning in developing nursing students’ critical thinking. Data …

HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration

HM Gao, H Zhou, F Zhang, BC Wilson… - Journal of …, 2011 - Soc Neuroscience
What drives the gradual degeneration of dopamine neurons in Parkinson's disease (PD), the
second most common neurodegenerative disease, remains elusive. Here, we demonstrated…

Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons

HM Gao, B Liu, JS Hong - Journal of Neuroscience, 2003 - Soc Neuroscience
Increasing evidence has suggested an important role for environmental toxins such as
pesticides in the pathogenesis of Parkinson's disease (PD). Chronic exposure to rotenone, a …

Novel anti-inflammatory therapy for Parkinson's disease

HM Gao, B Liu, W Zhang, JS Hong - Trends in pharmacological sciences, 2003 - cell.com
Parkinson's disease (PD) is a movement disorder that is characterized by progressive
degeneration of the nigrostriatal dopamine system. Although dopamine replacement can alleviate …

Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease

HM Gao, F Zhang, H Zhou, W Kam… - Environmental health …, 2011 - ehp.niehs.nih.gov
Background Mechanisms whereby gene–environment interactions mediate chronic, progressive
neurodegenerative processes in Parkinson’s disease (PD)—the second most common …