Endoplasmic-reticulum calcium depletion and disease

…, G Bultynck, JB Parys, H De Smedt… - Cold Spring …, 2011 - cshperspectives.cshlp.org
The endoplasmic reticulum (ER) as an intracellular Ca 2+ store not only sets up cytosolic
Ca 2+ signals, but, among other functions, also assembles and folds newly synthesized …

Abnormal intracellular Ca2+ homeostasis and disease

…, L Raeymaekers, B Nilius, J Eggermont, H De Smedt - Cell calcium, 2000 - Elsevier
A whole range of cell functions are regulated by the free cytosolic Ca 2+ concentration.
Activator Ca 2+ from the extracellular space enters the cell through various types of Ca 2+ …

[HTML][HTML] A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum

…, M Bittremieux, JB Parys, H De Smedt… - Biochimica et biophysica …, 2014 - Elsevier
Anti-apoptotic Bcl-2 contributes to cancer formation and progression by promoting the survival
of altered cells. Hence, it is a prime target for novel specific anti-cancer therapeutics. In …

Functional specialization of calreticulin domains

…, I Ahsan, R Krause, S Papp, H De Smedt… - The Journal of cell …, 2001 - rupress.org
Calreticulin is a Ca 2+ -binding chaperone in the endoplasmic reticulum (ER), and calreticulin
gene knockout is embryonic lethal. Here, we used calreticulin-deficient mouse embryonic …

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

…, F Zhong, JB Parys, H De Smedt… - Proceedings of the …, 2009 - National Acad Sciences
Although the presence of a BH4 domain distinguishes the antiapoptotic protein Bcl-2 from
its proapoptotic relatives, little is known about its function. BH4 deletion converts Bcl-2 into a …

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

…, JB Parys, H De Smedt… - Proceedings of the …, 2008 - National Acad Sciences
Imbalance of signals that control cell survival and death results in pathologies, including
cancer and neurodegeneration. Two pathways that are integral to setting the balance between …

[PDF][PDF] Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

…, MD Bootman, GA Mignery, JB Parys, H De Smedt… - Molecular cell, 2008 - cell.com
The antiapoptotic protein Bcl-2 inhibits Ca 2+ release from the endoplasmic reticulum (ER).
One proposed mechanism involves an interaction of Bcl-2 with the inositol 1,4,5-…

[HTML][HTML] The IP3 receptor–mitochondria connection in apoptosis and autophagy

…, G Monaco, G Bultynck, L Missiaen, H De Smedt… - … et Biophysica Acta (BBA …, 2011 - Elsevier
The amount of Ca 2+ taken up in the mitochondrial matrix is a crucial determinant of cell fate;
it plays a decisive role in the choice of the cell between life and death. The Ca 2+ ions …

2-Aminoethoxydiphenyl borate affects the inositol 1, 4, 5-trisphosphate receptor, the intracellular Ca2+ pump and the non-specific Ca2+ leak from the non …

L Missiaen, G Callewaert, H De Smedt, JB Parys - Cell calcium, 2001 - Elsevier
2-Aminoethoxydiphenyl borate (2APB) is a membrane-permeable blocker of the inositol 1,4,5-trisphosphate
(IP 3 )-induced Ca 2+ release in bi-directional Ca 2+ -flux conditions. We …

Intracellular Ca2+ storage in health and disease: a dynamic equilibrium

E Sammels, JB Parys, L Missiaen, H De Smedt… - Cell calcium, 2010 - Elsevier
Homeostatic control of the endoplasmic reticulum (ER) both as the site for protein handling (synthesis,
folding, trafficking, disaggregation and degradation) and as a Ca 2+ store is of …