In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate
glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-…

Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of HIF-1α and aryl
hydrocarbon receptor nuclear translocator (ARNT), plays a key role in cell survival and …

Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant
subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular …

Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly activated
myofibroblasts are the primary pathological driver of fibrotic progression, yet how various …

When oxygen sensing cells are excited by hypoxia, background K + currents are inhibited.
TASK-1, which is commonly expressed in oxygen sensing cells and makes a background K + …

The tumor-promoting factors β-catenin and hypoxia-inducible factor (HIF) are often found to
be coactivated in rapidly growing tumors. Recently, it was shown that HIF-1α negatively …

Directional anisotropic hardening under non-proportional loading is modeled. A recently
proposed coupled quadratic-nonquadratic (CQN) yield function (Lee et al., 2017b) successfully …

Stress integration algorithm based on finite difference method (FDM) was proposed to effectively
deal with both first and second derivatives of yield and potential functions which are the …

TCDD (2,3,7,8‐tetrachlorodibenzo‐p‐dioxin) is a highly toxic environmental contaminant.
When exposed to TCDD, mammalian cells undergo malignant transformation via abnormal …

Surface severe plastic deformation (SSPD) improves the mechanical behaviors of materials
by generating non-uniform, heterogeneous microstructures on their surfaces. SSPD …