Biochemistry of multidrug resistance mediated by the multidrug transporter
MM Gottesman, I Pastan - Annual review of biochemistry, 1993 - annualreviews.org
This year there will be approximately 1,000,000 new cases of cancer in the United States.
Close to half of these are still localized at the original site when the patient comes to the …
Close to half of these are still localized at the original site when the patient comes to the …
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
…, CA Hrycyna, M Ramachandra, I Pastan… - Annual review of …, 1999 - annualreviews.org
▪ Abstract Considerable evidence has accumulated indicating that the multidrug transporter
or P-glycoprotein plays a role in the development of simultaneous resistance to multiple …
or P-glycoprotein plays a role in the development of simultaneous resistance to multiple …
P-glycoprotein and multidrug resistance
MM Gottesman, I Pastan, SV Ambudkar - Current opinion in genetics & …, 1996 - Elsevier
Although the phenomenon of simultaneous resistance to multiple cytotoxic drugs (multidrug
resistance) in cancer cells has been discussed for more than two decades, and the human …
resistance) in cancer cells has been discussed for more than two decades, and the human …
[BOOK][B] Pakistan: A modern history
I Talbot - 2009 - eprints.soton.ac.uk
This book fills the need for a broad, historically sophisticated understanding of Pakistan, a
country which is understood by many in the West only in terms of stereotypes-the fanatical, …
country which is understood by many in the West only in terms of stereotypes-the fanatical, …
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.
…, MM Gottesman, IRA Pastan… - Proceedings of the …, 1987 - National Acad Sciences
Monoclonal antibody MRK16 was used to determine the location of P-glycoprotein, the
product of the multidrug-resistance gene (MDR1), in normal human tissues. The protein was …
product of the multidrug-resistance gene (MDR1), in normal human tissues. The protein was …
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
C Chen, JE Chin, K Ueda, DP Clark, I Pastan… - Cell, 1986 - cell.com
… Pastan, submitted). The human m&l gene is transferred ari’&lified in multidrug-resistant
transfectants of mouse NIH 3T3 cells, transfected with DNA from multidrug-resistant human …
transfectants of mouse NIH 3T3 cells, transfected with DNA from multidrug-resistant human …
Expression of a multidrug-resistance gene in human tumors and tissues.
…, MM Gottesman, I Pastan - Proceedings of the …, 1987 - National Acad Sciences
The identification and cloning of a segment of a human multidrug resistance gene (mdr1) was
reported recently. To examine the molecular basis of one type of multidrug resistance, we …
reported recently. To examine the molecular basis of one type of multidrug resistance, we …
Expression of multidrug resistance gene in human cancers
…, J Cossman, MM Gottesman, I Pastan - JNCI: Journal of the …, 1989 - academic.oup.com
Many cancers have been cured by chemotherapeutic agents. However, other cancers are
intrinsically drug resistant, and some acquire resistance following chemotherapy. Cloning of …
intrinsically drug resistant, and some acquire resistance following chemotherapy. Cloning of …
Expression of a full-length cDNA for the human" MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.
…, MM Gottesman, IRA Pastan - Proceedings of the …, 1987 - National Acad Sciences
Intrinsic and acquired multidrug resistance (MDR) is an important problem in cancer therapy.
MDR in human KB carcinoma cells selected for resistance to colchicine, vinblastine, or …
MDR in human KB carcinoma cells selected for resistance to colchicine, vinblastine, or …
Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.
K Chang, I Pastan - … of the National Academy of Sciences, 1996 - National Acad Sciences
Monoclonal antibody MAb K1 recognizes a 40-kDa glycoprotein present on the surface of
mesothelial cells, mesotheliomas, and ovarian cancers. We have used MAb K1 to isolate a …
mesothelial cells, mesotheliomas, and ovarian cancers. We have used MAb K1 to isolate a …