User profiles for I. M. Adcock

ian adcock

Imperial College
Verified email at imperial.ac.uk
Cited by 70202

Oxidative stress and redox regulation of lung inflammation in COPD

I Rahman, IM Adcock - European respiratory journal, 2006 - Eur Respiratory Soc
Reactive oxygen species, either directly or via the formation of lipid peroxidation products,
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …

Glucocorticoid resistance in inflammatory diseases

PJ Barnes, IM Adcock - The Lancet, 2009 - thelancet.com
Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several
common inflammatory diseases—including chronic obstructive pulmonary disease and acute …

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

KF Chung, IM Adcock - European Respiratory Journal, 2008 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality
that is characterised by inexorable deterioration of small airways obstruction with …

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

…, A Bush, M Castro, PJ Sterk, IM Adcock… - European respiratory …, 2014 - Eur Respiratory Soc
Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society, …

[HTML][HTML] Decreased histone deacetylase activity in chronic obstructive pulmonary disease

…, A Barczyk, S Hayashi, IM Adcock… - … England Journal of …, 2005 - Mass Medical Soc
Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
airway inflammation that is greater in patients with advanced disease. We asked whether there …

Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12

K Ito, PJ Barnes, IM Adcock - Molecular and cellular biology, 2000 - Am Soc Microbiol
… , a glucocorticoid agonist, indicates a time- and concentration-dependent reduction in CBP
and RNA polymerase II expression (IM Adcock and Y. Nasuhara, unpublished observations). …

Histone acetylation and deacetylation: importance in inflammatory lung diseases

PJ Barnes, IM Adcock, K Ito - European Respiratory Journal, 2005 - Eur Respiratory Soc
Inflammatory lung diseases are characterised by increased expression of multiple inflammatory
genes that are regulated by proinflammatory transcription factors, such as nuclear factor-…

Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression

…, B Cosio, M Ito, PJ Barnes, IM Adcock - The Journal of …, 2006 - rupress.org
Adcock; Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables
NF-… PJ Barnes, IM Adcock, and K. Ito have received nonrestricted funding from Boehringer …

Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages

…, KF Chung, PJ Barnes, IM Adcock - The FASEB …, 2001 - Wiley Online Library
Cigarette smoke is the major cause of chronic obstructive pulmonary disease (COPD), a
chronic inflammatory disease of the airway. The increased expression of inflammatory proteins …

Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD

…, CF Donner, PJ Barnes, IM Adcock - European …, 2002 - Eur Respiratory Soc
The expression of nuclear factor (NF)-κB is an indicator of cellular activation and of inflammatory
mediator production. The aim of the present study was to characterise the expression …