User profiles for I. M. Adcock
ian adcockImperial College Verified email at imperial.ac.uk Cited by 70202 |
Oxidative stress and redox regulation of lung inflammation in COPD
Reactive oxygen species, either directly or via the formation of lipid peroxidation products,
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …
Glucocorticoid resistance in inflammatory diseases
Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several
common inflammatory diseases—including chronic obstructive pulmonary disease and acute …
common inflammatory diseases—including chronic obstructive pulmonary disease and acute …
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality
that is characterised by inexorable deterioration of small airways obstruction with …
that is characterised by inexorable deterioration of small airways obstruction with …
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society, …
Task Force, supported by the European Respiratory Society and American Thoracic Society, …
[HTML][HTML] Decreased histone deacetylase activity in chronic obstructive pulmonary disease
…, A Barczyk, S Hayashi, IM Adcock… - … England Journal of …, 2005 - Mass Medical Soc
Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
airway inflammation that is greater in patients with advanced disease. We asked whether there …
airway inflammation that is greater in patients with advanced disease. We asked whether there …
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12
… , a glucocorticoid agonist, indicates a time- and concentration-dependent reduction in CBP
and RNA polymerase II expression (IM Adcock and Y. Nasuhara, unpublished observations). …
and RNA polymerase II expression (IM Adcock and Y. Nasuhara, unpublished observations). …
Histone acetylation and deacetylation: importance in inflammatory lung diseases
Inflammatory lung diseases are characterised by increased expression of multiple inflammatory
genes that are regulated by proinflammatory transcription factors, such as nuclear factor-…
genes that are regulated by proinflammatory transcription factors, such as nuclear factor-…
Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression
… Adcock; Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables
NF-… PJ Barnes, IM Adcock, and K. Ito have received nonrestricted funding from Boehringer …
NF-… PJ Barnes, IM Adcock, and K. Ito have received nonrestricted funding from Boehringer …
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages
Cigarette smoke is the major cause of chronic obstructive pulmonary disease (COPD), a
chronic inflammatory disease of the airway. The increased expression of inflammatory proteins …
chronic inflammatory disease of the airway. The increased expression of inflammatory proteins …
Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD
The expression of nuclear factor (NF)-κB is an indicator of cellular activation and of inflammatory
mediator production. The aim of the present study was to characterise the expression …
mediator production. The aim of the present study was to characterise the expression …