User profiles for I. S. Blagbrough
Ian BlagbroughUniversity of Bath Verified email at bath.ac.uk Cited by 4945 |
[HTML][HTML] Design and synthesis of hybrid compounds as novel drugs and medicines
AH Alkhzem, TJ Woodman, IS Blagbrough - RSC advances, 2022 - pubs.rsc.org
… He then received an MPhil from the University of Bath under the supervision of Dr IS
Blagbrough and Dr TJ Woodman on the analysis of clinically important aminoglycoside antibiotics, …
Blagbrough and Dr TJ Woodman on the analysis of clinically important aminoglycoside antibiotics, …
Cassava: An appraisal of its phytochemistry and its biotechnological prospects
IS Blagbrough, SAL Bayoumi, MG Rowan… - Phytochemistry, 2010 - Elsevier
The present state of knowledge of the phytochemistry of small molecules isolated from the
roots and leaves of cassava, Manihot esculenta Crantz (Euphorbiaceae), is reviewed. …
roots and leaves of cassava, Manihot esculenta Crantz (Euphorbiaceae), is reviewed. …
[HTML][HTML] In vitro evaluation of nasal aerosol depositions: an insight for direct nose to brain drug delivery
A Maaz, IS Blagbrough, PA De Bank - Pharmaceutics, 2021 - mdpi.com
… specific deposition within this area is confounded by a complex … it is used, and differences
in inter-patient physiology. In this review, an in-depth examination of these different factors is …
in inter-patient physiology. In this review, an in-depth examination of these different factors is …
Characterisation of the binding of [3H] methyllycaconitine: a new radioligand for labelling α7-type neuronal nicotinic acetylcholine receptors
ARL Davies, DJ Hardick, IS Blagbrough, BVL Potter… - …, 1999 - Elsevier
… Methyllycaconitine (MLA), a norditerpenoid alkaloid isolated from Delphinium seeds, is
one of the most potent non-proteinacious ligands that is selective for αbungarotoxin-sensitive …
one of the most potent non-proteinacious ligands that is selective for αbungarotoxin-sensitive …
Rapid and sensitive ethidium bromide fluorescence quenching assay of polyamine conjugate–DNA interactions for the analysis of lipoplex formation in gene therapy
AJ Geall, IS Blagbrough - Journal of pharmaceutical and biomedical …, 2000 - Elsevier
… optimised displacement assay is more reproducible than the exclusion assay, is more rapid
… low and high salt concentrations is complex as fluorescence is also salt dependent. However…
… low and high salt concentrations is complex as fluorescence is also salt dependent. However…
The condensation reaction between isocyanates and carboxylic acids. A practical synthesis of substituted amides and anilides.
IS Blagbrough, NE Mackenzie, C Ortiz, AI Scott - Tetrahedron letters, 1986 - Elsevier
… mixed anhydride is not isolated, indeed it is not … is converted into the unsubstituted amide
which is then treated with aqueous formaldehyde and the isolated N-hydroxymethyl amide is …
which is then treated with aqueous formaldehyde and the isolated N-hydroxymethyl amide is …
Constituents and secondary metabolite natural products in fresh and deteriorated cassava roots
…, MG Rowan, JR Beeching, IS Blagbrough - Phytochemistry, 2010 - Elsevier
… The tuberous root of cassava is the fourth most important food source in the tropics; it is a
staple food for more than 500 million people due to its high starch content. Although cassava is …
staple food for more than 500 million people due to its high starch content. Although cassava is …
Homologation of polyamines in the rapid synthesis of lipospermine conjugates and related lipoplexes
AJ Geall, IS Blagbrough - Tetrahedron, 2000 - Elsevier
… In order to reinforce these effects, it is apparently beneficial if a lipid moiety is covalently
bound to the polyamine, such a lipid can be cholesterol,24., 25. a bile acid, 26 or an aliphatic …
bound to the polyamine, such a lipid can be cholesterol,24., 25. a bile acid, 26 or an aliphatic …
An autoradiographic study of the distribution of binding sites for the novel α7‐selective nicotinic radioligand [3H]‐methyllycaconitine in the mouse brain
…, ARL Davies, MJ Marks, IS Blagbrough… - European journal of …, 1999 - Wiley Online Library
… B is the binding at the free ligand concentration L, B max is … sites, K d is the equilibrium
binding constant, and n is the Hill … where B is ligand bound at inhibitor concentration I, B o is the …
binding constant, and n is the Hill … where B is ligand bound at inhibitor concentration I, B o is the …
Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal α-bungarotoxin binding sites: Importance of the 2-(methylsuccinimido) benzoyl moiety for …
DJ Hardick, IS Blagbrough, G Cooper… - Journal of medicinal …, 1996 - ACS Publications
… This result indicates that the anthranoyl ester alone is insufficient for optimum potency,
and we propose that the 2-(S)-methylsuccinimido moiety of MLA is significant for its activity. …
and we propose that the 2-(S)-methylsuccinimido moiety of MLA is significant for its activity. …