User profiles for I. S. Blagbrough

Ian Blagbrough

University of Bath
Verified email at bath.ac.uk
Cited by 4945

[HTML][HTML] Design and synthesis of hybrid compounds as novel drugs and medicines

AH Alkhzem, TJ Woodman, IS Blagbrough - RSC advances, 2022 - pubs.rsc.org
… He then received an MPhil from the University of Bath under the supervision of Dr IS
Blagbrough and Dr TJ Woodman on the analysis of clinically important aminoglycoside antibiotics, …

Cassava: An appraisal of its phytochemistry and its biotechnological prospects

IS Blagbrough, SAL Bayoumi, MG Rowan… - Phytochemistry, 2010 - Elsevier
The present state of knowledge of the phytochemistry of small molecules isolated from the
roots and leaves of cassava, Manihot esculenta Crantz (Euphorbiaceae), is reviewed. …

[HTML][HTML] In vitro evaluation of nasal aerosol depositions: an insight for direct nose to brain drug delivery

A Maaz, IS Blagbrough, PA De Bank - Pharmaceutics, 2021 - mdpi.com
… specific deposition within this area is confounded by a complex … it is used, and differences
in inter-patient physiology. In this review, an in-depth examination of these different factors is

Characterisation of the binding of [3H] methyllycaconitine: a new radioligand for labelling α7-type neuronal nicotinic acetylcholine receptors

ARL Davies, DJ Hardick, IS Blagbrough, BVL Potter… - …, 1999 - Elsevier
… Methyllycaconitine (MLA), a norditerpenoid alkaloid isolated from Delphinium seeds, is
one of the most potent non-proteinacious ligands that is selective for αbungarotoxin-sensitive …

Rapid and sensitive ethidium bromide fluorescence quenching assay of polyamine conjugate–DNA interactions for the analysis of lipoplex formation in gene therapy

AJ Geall, IS Blagbrough - Journal of pharmaceutical and biomedical …, 2000 - Elsevier
… optimised displacement assay is more reproducible than the exclusion assay, is more rapid
… low and high salt concentrations is complex as fluorescence is also salt dependent. However…

The condensation reaction between isocyanates and carboxylic acids. A practical synthesis of substituted amides and anilides.

IS Blagbrough, NE Mackenzie, C Ortiz, AI Scott - Tetrahedron letters, 1986 - Elsevier
… mixed anhydride is not isolated, indeed it is not … is converted into the unsubstituted amide
which is then treated with aqueous formaldehyde and the isolated N-hydroxymethyl amide is

Constituents and secondary metabolite natural products in fresh and deteriorated cassava roots

…, MG Rowan, JR Beeching, IS Blagbrough - Phytochemistry, 2010 - Elsevier
… The tuberous root of cassava is the fourth most important food source in the tropics; it is a
staple food for more than 500 million people due to its high starch content. Although cassava is

Homologation of polyamines in the rapid synthesis of lipospermine conjugates and related lipoplexes

AJ Geall, IS Blagbrough - Tetrahedron, 2000 - Elsevier
… In order to reinforce these effects, it is apparently beneficial if a lipid moiety is covalently
bound to the polyamine, such a lipid can be cholesterol,24., 25. a bile acid, 26 or an aliphatic …

An autoradiographic study of the distribution of binding sites for the novel α7‐selective nicotinic radioligand [3H]‐methyllycaconitine in the mouse brain

…, ARL Davies, MJ Marks, IS Blagbrough… - European journal of …, 1999 - Wiley Online Library
… B is the binding at the free ligand concentration L, B max is … sites, K d is the equilibrium
binding constant, and n is the Hill … where B is ligand bound at inhibitor concentration I, B o is the …

Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal α-bungarotoxin binding sites: Importance of the 2-(methylsuccinimido) benzoyl moiety for …

DJ Hardick, IS Blagbrough, G Cooper… - Journal of medicinal …, 1996 - ACS Publications
… This result indicates that the anthranoyl ester alone is insufficient for optimum potency,
and we propose that the 2-(S)-methylsuccinimido moiety of MLA is significant for its activity. …