Amyloid deposits within the cerebral tissue constitute a characteristic lesion associated with
Alzheimer disease. They mainly consist of the amyloid peptide Aβ and display an abnormal …

Urotensin II (U-II) and urotensin II-related peptide (URP) are the endogenous ligands for the
orphan G-protein-coupled receptor GPR14 now renamed UT. At the periphery, U-II and/or …

PAC1 receptor is abundant in the CNS and plays an important role in neuronal survival. To
identify the molecular determinants and the conformational components responsible for the …

Urotensin II (UII) has been described as the most potent vasoconstrictor peptide and recognized
as the endogenous ligand of the orphan G protein-coupled receptor GPR14. Recently, a …

We have recently characterized bicarinalin as the most abundant peptide from the venom of
the ant Tetramorium bicarinatum. This antimicrobial peptide is active against …

A number of RFamide peptides have been characterized in invertebrate species and these
peptides have been found to exert a broad spectrum of biological activities. In contrast, in …

Microcin J25 (MccJ25) is the single macrocyclic antimicrobial peptide belonging to the
ribosomally synthesized class of microcins that are secreted by Enterobacteriaceae. It showed …

The SorLA protein, encoded by the SORL1 gene, is a major player in Alzheimer’s disease (AD)
pathophysiology. Functional and genetic studies demonstrated that SorLA deficiency …

A series of four fluorinated dipeptide analogues each containing a fluoro‐olefin moiety as
peptide bond surrogate has been designed and synthesized. These motifs have been …

Electronic circular dichroism is one of the most used spectroscopic techniques for peptide and
protein structural characterization. However, while valuable experimental spectra exist for …