Cyclin D‐Cdk4/6 and cyclin A/E‐Cdk2 are suggested to be involved in phosphorylation of
the retinoblastoma protein (pRB) during the G1/S transition of the cell cycle. However, it is …

As a first step in structure-based design of highly selective and potent Cdk4 inhibitors, we
performed structure-based generation of a novel series of Cdk4 inhibitors. A Cdk4 homology …

We screened cdc2 kinase inhibitors from cultured mediums of micro organisms using purified
mouse cyclin B-cdc2 kinase and a specific substrate peptide for cdc2 kinase. A selective …

Identification of a selective inhibitor for a particular protein kinase without inhibition of other
kinases is critical for use as a biological tool or drug. However, this is very difficult because …

Genetic alteration of one or more components of the p16 INK4A -CDK4,6/cyclin D-retinoblastoma
pathway is found in more than half of all human cancers. Therefore, CDK4 is an …

Transcription factor E2F-1 has a putative consensus sequence for phosphorylation by cyclin
dependent kinase (Ser-Pro-X-Lys/Arg). Therefore, we studied the phosphorylation of E2F-1 …

BACKGROUND Oncogenic RAS mutants such as v-Ha-RAS activate members of Rac/CDC42-dependent
kinases (PAKs) and appear to contribute to the development of more than 30…

D-type cyclin–dependent kinases (Cdk4 and Cdk6) regulate the G1 to S phase progression
of the mammalian cell cycle. It has been suggested that Cdk4 and Cdk6 may have distinct …

It has been postulated that the product (pRB) of the retinoblastoma gene dissociates from
the E2F-pRB complex upon phosphorylation by cyclin-dependent kinase (s)(cdk). However, …

Retinoblastoma protein (pRB) controls the G1/S transition in the cell cycle by binding and
inactivating E2F transcription factor. pRB changes the chromatin structure at the E2F-…